Immune responses of swine inoculated with a recombinant fowlpox virus co-expressing P12A and 3C of FMDV and swine IL-18.

Immune responses of swine inoculated with a recombinant fowlpox virus co-expressing P12A and 3C of FMDV and swine IL-18. Research Abstract Details 

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Immune responses of swine inoculated with a recombinant fowlpox virus co-expressing P12A and 3C of FMDV and swine IL-18. Abstract Text:

Mingxiao Ma,Ningyi Jin,Guoshun Shen,Guangze Zhu,Hui Juan Liu,Min Zheng,Huijun Lu,Xiaowei Huo,Minglan Jin,Gefen Yin,Haili Ma,Xu Li,Yue Ji,Kuoshi Jin,Mingxiao Ma,Ningyi Jin,Guoshun Shen,Guangze Zhu,Hui Juan Liu,Min Zheng,Huijun Lu,Xiaowei Huo,Minglan Jin,Gefen Yin,Haili Ma,Xu Li,Yue Ji,Kuoshi Jin,Mingxiao Ma,Ningyi Jin,Guoshun Shen,Guangze Zhu,Hui Juan Liu,Min Zheng,Huijun Lu,Xiaowei Huo,Minglan Jin,Gefen Yin,Haili Ma,Xu Li,Yue Ji,Kuoshi Jin,

Two recombinant fowlpox viruses (rFPV-P1 and rFPV-IL18-2AP12A) containing foot-and-mouth disease virus (FMDV) capsid polypeptide, 3C coding regions of O/NY00 were evaluated to determine their abilities to induce humoral and cellular responses in the presence or absence of swine IL-18 as genetic adjuvant. The ability to protect swine against homologous virus challenge was examined. All swine were given booster vaccinations at 21 days after the initial inoculation and were challenged 10 days after the booster vaccination. Control groups were inoculated with wild-type fowlpox virus (wtFPV). All animals vaccinated with rFPV-P12A and rFPV-IL18-P12A developed specific anti-FMDV ELISA antibody and neutralizing antibody and T-lymphocyte proliferation was observed. Cellular immune function was evaluated via examination of IFN-gamma production in swine peripheral blood serum. The results demonstrate the potential viability of a fowlpox virus-based recombinant vaccine in the control and prevention of FMDV infections.

Immune responses of swine inoculated with a recombinant fowlpox virus co-expressing P12A and 3C of FMDV and swine IL-18. Publishing Authors By Initials

M Ma,N Jin,G Shen,G Zhu,HJ Liu,M Zheng,H Lu,X Huo,M Jin,G Yin,H Ma,X Li,Y Ji,K Jin,M Ma,N Jin,G Shen,G Zhu,HJ Liu,M Zheng,H Lu,X Huo,M Jin,G Yin,H Ma,X Li,Y Ji,K Jin,M Ma,N Jin,G Shen,G Zhu,HJ Liu,M Zheng,H Lu,X Huo,M Jin,G Yin,H Ma,X Li,Y Ji,K Jin,

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Immune responses of swine inoculated with a recombinant fowlpox virus co-expressing P12A and 3C of FMDV and swine IL-18. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Veterinary immunology and immunopathology

VOLUME: 121

Page Numbers: 1-7

Journal Abbreviation: Vet. Immunol. Immunopathol.

ISSN: 0165-2427

DAY: 28

MONTH: 06

YEAR: 2007

Immune responses of swine inoculated with a recombinant fowlpox virus co-expressing P12A and 3C of FMDV and swine IL-18. Information

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LANGUAGE: eng

NlmUniqueID: 8002006

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Grant and Affiliation Information for Immune responses of swine inoculated with a recombinant fowlpox virus co-expressing P12A and 3C of FMDV and swine IL-18.

AFFILIATION: Genetic Engineering Laboratory, Academy of Military Medical Sciences, Changchun 130062, PR China; College of Animal Science and Veterinary Medicine, Liaoning Medical University, Jinzhou 121001, PR China.

Country: Netherlands

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MEDLINETA: Vet Immunol Immunopathol

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