Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat.

Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat. Research Abstract Details 

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Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat. Abstract Text:

The immune response in rats to gamma-irradiated human amnion and human skin collagen was characterized through histologic and immunologic methods. Pepsin-extracted human amnion collagen and skin collagen were purified and reconstituted. Implants of amnion collagen demonstrated greater persistence than skin collagen. For amnion collagen implants, no significant inflammatory response was found. Fibroblast and adipocyte ingrowth and neovascularization were present. Conversely, obvious inflammatory infiltration was evident in the skin collagen implants. Enzyme-linked immunosorbent assay results showed that anti-amnion collagen antibody levels were significantly lower than anti-skin collagen antibody levels against their respective implant materials. The ratios of type I to type III collagen are 56:44 and 95:5 for amnion collagen and skin collagen, respectively. These findings suggest that in this heterologous type system, type III collagen-rich amnion collagen preparations appear superior to skin collagen for soft-tissue augmentation.

Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat. Publishing Authors By Initials

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of dermatology

VOLUME: 125

Page Numbers: 1084-9

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Aug

YEAR: 1989

Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: immunology

Chemical & Substance for Abstract: Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat.

AFFILIATION: Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.

Country: UNITED STATES

AGENCY: United States NCRR

GRANT: RR-00350

ACRONYM: RR

MEDLINETA: Arch Dermatol

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