Immune response of the gastric mucosa to Campylobacter pylori.

Immune response of the gastric mucosa to Campylobacter pylori. Research Abstract Details 

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Immune response of the gastric mucosa to Campylobacter pylori. Abstract Text:

J I Wyatt,B J Rathbone,

The histological features of non-autoimmune chronic gastritis are consistent with those of a local immune response by the gastric mucosa. If Campylobacter pylori is causative in this condition, then the immune response will be in part specific for this organism. Antibodies to C. pylori are present in the gastric juice of infected patients. Coating of mucosal C. pylori by antibody in vivo can be demonstrated by immunohistochemistry, and a neutrophil infiltrate (active gastritis) is associated with coating by opsonising antibodies. Gastric mucosa from patients with C. pylori produces specific immunoglobulin in vitro, and this antibody production correlates with the plasma cell infiltrate seen in these patients. Lymphoid follicles in gastric mucosa, implying local antigenic stimulation, are a specific feature of campylobacter-associated gastritis. The inflammation gradually abates following eradication of the bacteria. We conclude that the morphological features of campylobacter-associated gastritis represent the immune response of the mucosa to C. pylori.

Immune response of the gastric mucosa to Campylobacter pylori. Publishing Authors By Initials

JI Wyatt,BJ Rathbone,

For similar tissues: lymphoid tissue research abstracts see: tissues: lymphoid tissue research

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Immune response of the gastric mucosa to Campylobacter pylori. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 142

Page Numbers: 44-9

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1988

Immune response of the gastric mucosa to Campylobacter pylori. Information

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LANGUAGE: eng

NlmUniqueID: 437034

Immune response of the gastric mucosa to Campylobacter pylori. Keywords Mesh Terms:

KEYWORDS: Lymphoid Tissue

MESH TERMS: pathology

Chemical & Substance for Abstract: Immune response of the gastric mucosa to Campylobacter pylori. Information

Substance Name: Immunoglobulins

Registry Number: 0

Grant and Affiliation Information for Immune response of the gastric mucosa to Campylobacter pylori.

AFFILIATION: Department of Pathology, St. James's University Hospital, Leeds, UK.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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