Immune mechanisms leading to drug-induced blood dyscrasias.

Immune mechanisms leading to drug-induced blood dyscrasias. Research Abstract Details 

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Immune mechanisms leading to drug-induced blood dyscrasias. Abstract Text:

Drug-induced blood dyscrasias may be due to toxicity of the drug, inborn errors of metabolism or immunological reactions. In the latter case, drug-induced antibodies are directed to specific target cells, such as platelets (thrombocytopenia) or granulocytes (agranulocytosis). Some of these immune mechanisms are based on the physical interaction between drug, antibody and target cells. A particular drug may bind to the surface of the blood cell which, as a carrier of the drug, will be destroyed as part of the immune reaction to the drug (hapten mechanism). Other drugs will form immune complexes with drug-specific antibodies. These immune complexes will bind to certain blood cells and destroy them as innocent bystanders (immune complex mechanism). In vitro assays are described which enable the offending drug to be detected by mimicking these immune mechanisms using patient serum, platelets or granulocytes, and the suspected drug. The diagnostic value of these in vitro assays is discussed.

Immune mechanisms leading to drug-induced blood dyscrasias. Publishing Authors By Initials

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Immune mechanisms leading to drug-induced blood dyscrasias. Journal Published:

PUBLICATION TYPE: Review

Journal: European journal of haematology. Supplementum

VOLUME: 60

Page Numbers: 64-8

Journal Abbreviation:

ISSN: 0902-4506

DAY: 26

MONTH: 02

YEAR: 1996

Immune mechanisms leading to drug-induced blood dyscrasias. Information

Number of References: 23

LANGUAGE: eng

NlmUniqueID: 8703474

Immune mechanisms leading to drug-induced blood dyscrasias. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

Chemical & Substance for Abstract: Immune mechanisms leading to drug-induced blood dyscrasias. Information

Substance Name: Antibodies

Registry Number: 0

Grant and Affiliation Information for Immune mechanisms leading to drug-induced blood dyscrasias.

AFFILIATION: Department of Immunohaematology, Leiden Academic Hospital, The Netherlands.

Country: DENMARK

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MEDLINETA: Eur J Haematol Suppl

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