Immune events associated with inflammatory bowel disease.

Immune events associated with inflammatory bowel disease. Research Abstract Details 

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Immune events associated with inflammatory bowel disease. Abstract Text:

C Fiocchi,

Immunologic abnormalities have been implicated in the etiology of inflammatory bowel disease (IBD). Defects of systemic immunity and of local (intestinal) immunity have been studied. The numbers of T and B lymphocytes and their characteristics seem to vary with the disease, but no cause-and-effect relationship has been established. The presence of anticolon antibodies in patients with ulcerative colitis suggests that these antibodies could be involved in IBD, but they have also been found in other conditions. In the peripheral blood, abnormalities of cell-mediated immunity are inconsistent and suggest that they are not fundamental defects of the disease. The hypothesis that the inflammatory process is a result of immune-mediated intestinal tissue damage is being extensively studied. The high familial incidence of the disease suggests a role of histocompatibility locus antigens, but no reproducible association can be established. In vivo and in vitro studies of mucosal mononuclear cells have revealed abnormalities of immunoglobulin production, some types of cytotoxicity against gut-derived antigens, and altered lymphokine production associated with the disease. Further studies of the intestinal immune system would seem to be the most fruitful line of research.

Immune events associated with inflammatory bowel disease. Publishing Authors By Initials

C Fiocchi,

For similar tissues: membranes: mucous membrane research abstracts see: tissues: membranes: mucous membrane research

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Immune events associated with inflammatory bowel disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 172

Page Numbers: 4-12

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1990

Immune events associated with inflammatory bowel disease. Information

Number of References: 75

LANGUAGE: eng

NlmUniqueID: 437034

Immune events associated with inflammatory bowel disease. Keywords Mesh Terms:

KEYWORDS: Mucous Membrane

MESH TERMS: immunology

Chemical & Substance for Abstract: Immune events associated with inflammatory bowel disease. Information

Substance Name: HLA Antigens

Registry Number: 0

Grant and Affiliation Information for Immune events associated with inflammatory bowel disease.

AFFILIATION: Dept. of Gastroenterology, Cleveland Clinic Foundation, Ohio 44195.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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