Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration.

Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration. Research Abstract Details 

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Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration. Abstract Text:

Tracy Jane Stefonek,Kristyn S Masters,Tracy Jane Stefonek,Kristyn S Masters,

Acceleration of wound closure results not only in decreased patient suffering and cost of wound treatment, but may also minimize scarring and lead to formation of a more stable closed wound. Cell migration is a critical element in wound healing, and it is believed that the ability to control the migration direction of cells will lead to accelerated closure of wounds. Thus, we have synthesized surfaces that are covalently modified with gradients of epidermal growth factor (EGF), a key molecule in the native wound-healing process, in order to create a platform that promotes directed cell migration. Standard photo-patterning techniques used herein enabled precise control over the spatial location of tethered EGF and the fabrication and quantitative characterization of gradient patterns of different types and slopes. Under serum-free conditions, human epidermal keratinocytes on immobilized EGF gradients preferentially migrated in the direction of higher EGF concentrations, and exhibited unidirectional migration speed and distance that was over five-fold greater than that observed on control surfaces. Treatment of migrating cells with an inhibitor of the EGF receptor resulted in immediate cessation of migration, thus verifying that the observed migration trends were directly attributable to keratinocyte interactions with immobilized EGF.

Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration. Publishing Authors By Initials

TJ Stefonek,KS Masters,TJ Stefonek,KS Masters,

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Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Wound repair and regeneration : official publicati

VOLUME: 15

Page Numbers: 847-55

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ISSN: 1067-1927

DAY: 21

MONTH: 11

YEAR: 2007

Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration. Information

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LANGUAGE: eng

NlmUniqueID: 9310939

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Grant and Affiliation Information for Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration.

AFFILIATION: Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Country: United States

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MEDLINETA: Wound Repair Regen

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