Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats.

Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats. Research Abstract Details 

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Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats. Abstract Text:

I Kobrin,A Gallo,A Kumar,B L Pegram,E D Frohlich,

The immediate effects on regional and systemic hemodynamics of urapidil (1 mg/kg IV), a recently synthesized vasodilator with a possible combined central and peripheral action, were studied in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Maximal decrease in mean arterial pressure was achieved within the first minute after injection (154 +/- 4 vs 113 +/- 6 mm Hg in SHR and 111 +/- 4 vs 82 +/- 4 mm Hg in WKY, p less than 0.01). This effect was accompanied by a transient (10 min) significant increase in heart rate in both strains. There was a significant fall in total peripheral resistance (0.43 +/- 0.02 vs 0.30 +/- 0.02 U/kg in WKY and 0.62 +/- 0.03 vs 0.43 +/- 0.03 U/kg in SHR, p less than 0.01) and rise in cardiac index 15 min after drug injection (371 +/- 9 vs 425 +/- 12 ml/min/kg in WKY and 395 +/- 8 vs 432 +/- 112 ml/min/kg in SHR, p less than 0.01). Organ vascular resistance decreased significantly in all the organs of /KY and most of the organs of SHR rats. However, a significant increase in blood flow was observed only in skeletal muscle. The data indicate that urapidil is a potent hypotensive agent. The pressure fall is mediated through a decreased total peripheral resistance that is distributed through all circulations. The increased cardiac output and heart rate are most likely reflexly induced.

Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats. Publishing Authors By Initials

I Kobrin,A Gallo,A Kumar,BL Pegram,ED Frohlich,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research

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Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 6

Page Numbers: 685-97

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1984

Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats. Keywords Mesh Terms:

KEYWORDS: Vascular Resistance

MESH TERMS: drug effects

Chemical & Substance for Abstract: Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats. Information

Substance Name: urapidil

Registry Number: 34661-75-1

Grant and Affiliation Information for Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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