Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors.

Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Research Abstract Details 

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Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Abstract Text:

Renae C Streblow,Alicia J Dafferner,Marilu Nelson,Mavis Fletcher,William W West,Rachel K Stevens,Zoran Gatalica,Deborah Novak,Julia A Bridge,Renae C Streblow,Alicia J Dafferner,Marilu Nelson,Mavis Fletcher,William W West,Rachel K Stevens,Zoran Gatalica,Deborah Novak,Julia A Bridge,

Traditional cytogenetic studies of ovarian stromal tumors are few, although trisomy 12 has been frequently documented with fluorescence in situ hybridization (FISH). In the current study, karyotypic analysis of four ovarian stromal tumors and a review of the literature suggest that numerical abnormalities of chromosomes 4 and 9 might also be important, possibly as secondary changes. To determine the frequency of 4, 9, and 12 aneuploidy in a larger group of ovarian tumors, FISH studies were performed on eight fibromas, three thecomas, one fibrothecoma, and five cellular fibromas. Trisomy 12 was identified in all five cellular fibromas as well as in two fibromas and the fibrothecoma. Gain of chromosome 9 was confined to the cellular fibromas. Loss of chromosomes 4 and/or 9 was prominent in the fibromas. These findings confirm the presence of trisomy 12 as a nonrandom chromosomal abnormality in ovarian stromal tumors. Moreover, these conventional and molecular cytogenetic data indicate that gain of chromosome 9 in addition to gain of chromosome 12 is prominent in cellular fibroma. In contrast, loss of chromosomes 4 and/or 9 are recurrent in fibroma. In summary, imbalances of chromosomes 4 and 9 appear to represent important secondary abnormalities in the thecoma-fibroma ovarian tumor group.

Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Publishing Authors By Initials

RC Streblow,AJ Dafferner,M Nelson,M Fletcher,WW West,RK Stevens,Z Gatalica,D Novak,JA Bridge,RC Streblow,AJ Dafferner,M Nelson,M Fletcher,WW West,RK Stevens,Z Gatalica,D Novak,JA Bridge,

For similar neoplasms: neoplasms by histologic type: neoplasms, gonadal tissue: sex cord-gonadal stromal tumors: thecoma research abstracts see: neoplasms: neoplasms by histologic type: neoplasms, gonadal tissue: sex cord-gonadal stromal tumors: thecoma research

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Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer genetics and cytogenetics

VOLUME: 178

Page Numbers: 135-40

Journal Abbreviation: Cancer Genet. Cytogenet.

ISSN: 0165-4608

DAY: 15

MONTH: Oct

YEAR: 2007

Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Information

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LANGUAGE: eng

NlmUniqueID: 7909240

Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Keywords Mesh Terms:

KEYWORDS: Thecoma

MESH TERMS: pathology

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Grant and Affiliation Information for Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors.

AFFILIATION: Departments of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA.

Country: United States

AGENCY: United States NCI

GRANT: P30 CA3672

ACRONYM: CA

MEDLINETA: Cancer Genet Cytogenet

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