Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement.

Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. Research Abstract Details 

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Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. Abstract Text:

J Mandelin,T F Li,M Liljeström,M E Kroon,R Hanemaaijer,S Santavirta,Y T Konttinen,

In the differentiation of osteoclasts the differentiation factor (RANKL) interacts with the receptor activator of NF-kappaB (RANK) in a direct cell-to-cell contact between osteoblast and (pre)osteoclast. This is inhibited by soluble osteoprotegerin (OPG). The mRNA levels of both RANKL (p < 0.01) and RANK (p < 0.05) were high in peri-implant tissue and RANKL+ and RANK+ cells were found in such tissue. Double labelling also disclosed soluble RANKL bound to RANK+ cells. We were unable to stimulate fibroblasts to express RANKL in vitro, but monocyte activation with LPS gave a fivefold increase in RANK mRNA levels. In contrast to RANKL and RANK expression in peri-implant tissue, expression of OPG was restricted to vascular endothelium. Endothelial cell OPG mRNA levels were regulated by TNF-alpha and VEGF, but not by hypoxia. It is concluded that activated cells in the interface tissue overproduce both RANKL and RANK and they can interact without interference by OPG.

Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. Publishing Authors By Initials

J Mandelin,TF Li,M Liljeström,ME Kroon,R Hanemaaijer,S Santavirta,YT Konttinen,

For similar musculoskeletal system: skeleton: joints: joint capsule: synovial membrane research abstracts see: musculoskeletal system: skeleton: joints: joint capsule: synovial membrane research

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Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of bone and joint surgery. British vol

VOLUME: 85

Page Numbers: 1196-201

Journal Abbreviation:

ISSN: 0301-620X

DAY: 14

MONTH: Nov

YEAR: 2003

Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. Information

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LANGUAGE: eng

NlmUniqueID: 375355

Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. Keywords Mesh Terms:

KEYWORDS: Synovial Membrane

MESH TERMS: metabolism

Chemical & Substance for Abstract: Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. Information

Substance Name: TNFSF11 protein, human

Registry Number: 0

Grant and Affiliation Information for Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement.

AFFILIATION: Institute of Biomedicine/Anatomy, Biomedicum Helsinki, University of Helsinki, Finland.

Country: England

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MEDLINETA: J Bone Joint Surg Br

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