Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner.

Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner. Research Abstract Details 

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Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner. Abstract Text:

Jinfei Chen,Anita Schmitt,Krzysztof Giannopoulos,Baoan Chen,Markus Rojewski,Hartmut ,Donald Bunjes,Michael Schmitt,Jinfei Chen,Anita Schmitt,Krzysztof Giannopoulos,Baoan Chen,Markus Rojewski,Hartmut ,Donald Bunjes,Michael Schmitt,

The tyrosine kinase inhibitor imatinib has been reported to inhibit CD8+ T lymphocytes. Little is known about its effects on CD4+CD25+ regulatory T cells (T(reg) cells) which might regulate the graft-vs.-leukemia (GVL) reaction after allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusion (DLI). This is of particular interest in patients with relapse of chronic myeloid leukemia (CML) after allo-SCT, as the two therapeutical options DLI and imatinib might interact reversely. Here, we demonstrate that the proliferation of CD4+CD25+ T(reg) cells and their production of IL-10, TGF-beta1 and granzyme B as markers of activation were significantly down-regulated by imatinib in a dose-dependent manner. In addition, the expression of surface CD69, both surface and intracellular GITR, FoxP3, CD152 (CTLA) of activated CD4+CD25+ T(reg) cells were inhibited by imatinib in a dose-dependent manner. In light of these findings, clinical administration of imatinib might not result in a reduction of the GVL effect on CML patients receiving imatinib after allo-SCT and/or DLI or other CD8+ T lymphocyte based immunotherapies as the function of CD8+ cytotoxic T lymphocytes and CD4+CD25(hi) Treg cells is hampered in a similar way by imatinib.

Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner. Publishing Authors By Initials

J Chen,A Schmitt,K Giannopoulos,B Chen,M Rojewski,H ,D Bunjes,M Schmitt,J Chen,A Schmitt,K Giannopoulos,B Chen,M Rojewski,H ,D Bunjes,M Schmitt,

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Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of oncology

VOLUME: 31

Page Numbers: 1133-9

Journal Abbreviation: Int. J. Oncol.

ISSN: 1019-6439

DAY: 3

MONTH: Nov

YEAR: 2007

Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner. Information

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LANGUAGE: eng

NlmUniqueID: 9306042

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Grant and Affiliation Information for Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner.

AFFILIATION: Department of Internal Medicine III, University Clinic, Robert-Koch-Strasse 8, D-89081 Ulm, Germany.

Country: Greece

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MEDLINETA: Int J Oncol

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