Imaging the Abeta-related neurotoxicity of Alzheimer disease.

Imaging the Abeta-related neurotoxicity of Alzheimer disease. Research Abstract Details 

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Imaging the Abeta-related neurotoxicity of Alzheimer disease. Abstract Text:

Herman Moreno,William E Wu,Thomas Lee,Adam Brickman,Richard Mayeux,Truman R Brown,Scott A Small,Herman Moreno,William E Wu,Thomas Lee,Adam Brickman,Richard Mayeux,Truman R Brown,Scott A Small,

BACKGROUND: Neurotoxicity related to the Abeta peptide is thought to be a primary mechanism of dysfunction in Alzheimer disease (AD). Although numerous imaging studies have observed brain dysfunction in AD, whether these imaged defects reflect Abeta-related neurotoxicity remains unknown. OBJECTIVE: To study Abeta-related neurotoxicity by means of functional imaging maps of the hippocampal formation in human patients and mouse models. DESIGN: Cross-sectional study comparing humans with AD and control subjects, cross-sectional study of J20 mice, a transgenic mouse model of AD, and a longitudinal study of flurbiprofen administration to transgenic mice. SETTING: Alzheimer disease research center. Subjects Eleven subjects with probable Alzheimer disease and 11 age-matched controls, plus J20 mice and wild-type littermates. INTERVENTIONS: In the first study, human subjects and controls underwent magnetic resonance imaging. In the second study, mice underwent imaging at 3, 6, 12, 15, and 21 months of age, for a total of 57 imaging experiments. In the third study, 12 J20 mice underwent imaging repeatedly over time; 6 received flurbiprofen to ameliorate Abeta-related neurotoxicity and 6 received vehicle control. MAIN OUTCOME MEASURES: Comparison of hippocampal functional maps. RESULTS: Among all hippocampal subregions, the entorhinal cortex was the dominant site of dysfunction observed in both human patients and J20 mice. Long-term administration of flurbiprofen rescued entorhinal cortex dysfunction in transgenic mice. CONCLUSION: Our results establish that the neurotoxicity related to the Abeta peptide can be captured in vivo by functional imaging and suggest hippocampal subregions most vulnerable to its toxic effects.

Imaging the Abeta-related neurotoxicity of Alzheimer disease. Publishing Authors By Initials

H Moreno,WE Wu,T Lee,A Brickman,R Mayeux,TR Brown,SA Small,H Moreno,WE Wu,T Lee,A Brickman,R Mayeux,TR Brown,SA Small,

For similar nervous system diseases: neurotoxicity syndromes research abstracts see: nervous system diseases: neurotoxicity syndromes research

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Imaging the Abeta-related neurotoxicity of Alzheimer disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of neurology

VOLUME: 64

Page Numbers: 1467-77

Journal Abbreviation: Arch. Neurol.

ISSN: 0003-9942

DAY: 20

MONTH: Oct

YEAR: 2007

Imaging the Abeta-related neurotoxicity of Alzheimer disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372436

Imaging the Abeta-related neurotoxicity of Alzheimer disease. Keywords Mesh Terms:

KEYWORDS: Neurotoxicity Syndromes

MESH TERMS: pathology

Chemical & Substance for Abstract: Imaging the Abeta-related neurotoxicity of Alzheimer disease. Information

Substance Name: Flurbiprofen

Registry Number: 5104-49-4

Grant and Affiliation Information for Imaging the Abeta-related neurotoxicity of Alzheimer disease.

AFFILIATION: Department of Neurology, Robert S. Furchgott Center for Neural and Behavioral Sciences, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.

Country: United States

AGENCY: United States NIA

GRANT: AG027476

ACRONYM: AG

MEDLINETA: Arch Neurol

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