Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI.

Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI. Abstract Text:

James H Holmes,Frank R Korosec,Jiang Du,Rafael L O'Halloran,Ronald L Sorkness,Thomas M Grist,Janet E Kuhlman,Sean B Fain,

PURPOSE: To image respiratory dynamics and three-dimensional (3D) ventilation during inhalation, breath-hold, and exhalation for evaluation of obstructive lung disease using a single dose of hyperpolarized (HP) He-3 during MRI. MATERIALS AND METHODS: A single 2D-3D projections inside Z encoding (PRIZE)-2D acquisition was performed that consisted of a rapid 2D radial acquisition phase during inhalation of the HP He-3, a 3D acquisition phase during a breath-hold interval, and finally the same 2D radial acquisition during a forced exhalation maneuver followed by tidal breathing. The 3D PRIZE acquisition was comprised of radial sampling in the coronal plane and Fourier encoding in the patient's anterior-posterior direction. Nine patients with mild/moderate to severe asthma were studied (two individuals were studied twice) using this technique. RESULTS: Breath-hold and dynamic imaging results showed physiological abnormalities and were compared with results from standard spirometry, body plethysmography, and computed tomography (CT). Dynamic images depicted regions of differential gas clearance and trapping observed during and after forced exhalation that were corroborated as regions of air trapping on CT imaging. CONCLUSION: The 2D-3D PRIZE-2D acquisition allowed for 3D depiction of ventilation during a breath-hold, as well as detection of gas trapping. Imaging results were confirmed with spirometry, body plethysmography, and CT.

Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI. Publishing Authors By Initials

JH Holmes,FR Korosec,J Du,RL O'Halloran,RL Sorkness,TM Grist,JE Kuhlman,SB Fain,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

PUBMED ID PMID:

MEDLINE DATE:

Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 26

Page Numbers: 630-6

Journal Abbreviation:

ISSN: 1053-1807

DAY: 3

MONTH: Sep

YEAR: 2007

Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9105850

Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: methods

Chemical & Substance for Abstract: Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI. Information

Substance Name: Contrast Media

Registry Number: 0

Grant and Affiliation Information for Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI.

AFFILIATION: Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Country: United States

AGENCY: United States NCI

GRANT: T32-CA09206-26

ACRONYM: CA

MEDLINETA: J Magn Reson Imaging

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI Related Publications

• AADE's diabetes education outcomes project.
• Content and metabolism of mucopolysaccharides in CNS tissues during development of brain tumors in rats.
• Current trends in vector control A review.
• Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunity.
• Dipetalonema semiclarum sp. nov. from the blood of man in the Republic of Zaire (Nematoda : Filarioidea).
• Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI.
• Iterative projection reconstruction of time-resolved images using highly-constrained back-projection (HYPR).
• New CIAS1 mutation and anakinra efficacy in overlapping of Muckle-Wells and familial cold autoinflammatory syndromes.
• Predicting the likelihood of future sexual recidivism: pilot study findings from a california sex offender risk project and cross-validation of the static-99.
• Psychometric properties of the Spanish Version of the Diabetes Self-management Assessment Report Tool.
• Recognizing a job well done!
• TEM transmission line coil with double nuclear capability.
• The pentastomida parasitic in man.
• [Antibiotics in the treatment of acute uncomplicated gonorrhea in males.]
• [Benign and malignant neoplastic tumors in the negro of the Bahutu race in Ruanda-Urundi.]
• [Contribution to the study of malaria in high altitudes.]
• [Description of a new organ, probably with respiratory function, in pupae of Simulium in the Afrotropical region]
• [Epidemiology and pathology of loaiasis]
• [Geographic distribution of the filaria Loa loa and of the tabanid Chrysops in the Congo and Rwanda]
• [Infestation by Onchocerca volvulus in the Lusambo region (East Kasai, Zaire), Parasitological, ophthalmological and immunologic aspects]
• [Intradermal parasitism due to Nematodes in Rwandese cattle. Description of 2 new species]
• [Introduction to the study of bilharziasis]
• [Notes on a focus of endemic goiter situated on the banks of the Kwango (Congo-Kinshasa)]
• [Notes on the geographical distribution of the filaria Loa Loa and the tabanids of the genus Chrysops in Congo and in Rwanda. Addenda and corrigenda]
• [Onchocerciasis in the Congo basin]
• [Parasitic diseases in Europe]
• [Results of treatment of acute gonorrhea in accordance with existing instructions and schemes.]
• [Summary of reports]
• [The glossina of the Kabambare region (Maniema, Eastern Zaire)]
• [Why must filariases be fought?]