Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595.

Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595. Abstract Text:

O D Hughes,A C Perkins,M Frier,M L Wastie,G Denton,M R Price,H Denley,M C Bishop,

OBJECTIVE: To investigate the clinical application of an 111In-labelled anti-MUC1 mucin monoclonal antibody (mAb) imaging for staging invasive bladder cancer. PATIENTS AND METHODS: Indirect immunohistochemistry was used to confirm the expression of the MUC1 target antigen by metastatic tumours. Twelve patients with bladder cancer (two with superficial and 10 with locally invasive/metastatic disease) underwent planar gamma-scintigraphy 48 h after an intravenous injection with 111In-labelled anti-MUC1 mucin mAb C595. RESULTS: No bladder uptake was detected in the two patients with superficial disease, but scintigraphy showed primary and recurrent bladder tumours and metastases in nine of the remaining 10 patients with invasive disease. In three patients additional staging information was obtained from the mAb imaging which would have altered patient management. There were no reported side-effects. CONCLUSION: This study confirmed the ability of the mAb technique to detect both primary and recurrent invasive bladder tumours and distant metastases. Some lesions shown by mAb imaging were not detected by other methods. The use of mAb imaging has the potential to improve clinical staging and assist in selecting those patients most likely to benefit from radical therapy.

Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595. Publishing Authors By Initials

OD Hughes,AC Perkins,M Frier,ML Wastie,G Denton,MR Price,H Denley,MC Bishop,

For similar neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BJU international

VOLUME: 87

Page Numbers: 39-46

Journal Abbreviation: BJU Int.

ISSN: 1464-4096

DAY: 1

MONTH: Jan

YEAR: 2001

Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100886721

Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder Neoplasms

MESH TERMS: radionuclide imaging

Chemical & Substance for Abstract: Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595. Information

Substance Name: Peptide Fragments

Registry Number: 0

Grant and Affiliation Information for Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595.

AFFILIATION: Department of Urology, City Hospital, Nottingham, UK.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: BJU Int

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595 Related Publications

• 99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer.
• Application of mulch for treating metals in urban runoff: batch and column test.
• Curing dyslexia and attention-deficit hyperactivity disorder by training motor co-ordination: miracle or myth?
• Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes.
• Distinct pathways of genomic progression to benign and malignant tumors of the liver.
• Effects of growth factors on the differentiation of murine ESC into type II pneumocytes.
• Ethics, justification and the prevention of spina bifida.
• Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system.
• Genetic perspectives on host responses to porcine reproductive and respiratory syndrome (PRRS).
• Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595.
• Immunoendocrine response to cycling following ingestion of caffeine and carbohydrate.
• Immunology at the University of Iowa.
• Influence of muscle fiber composition on oxygen uptake kinetics: 2051: board #121 may 31 3:30 PM - 5:00 PM.
• Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.
• Lipid A modification systems in gram-negative bacteria.
• Maternal complications of pregnancy increase beyond 40 weeks of gestation in low-risk women.
• Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.
• Molecular and macroscopic aspects of cavity formation in the hydrophobic effect.
• Prevalence of Eating Disorders: Effects of Body Image and Anthropometric Measures in Auxiliary Units: 2256: Board #169 June 1 8:00 AM - 9:30 AM.
• Production and characterisation of a C595 antibody-99mTc conjugate for immunoscintigraphy of bladder cancer.
• RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors.
• Recovery rate of embryonic stem cells after defrosting: role of the feeder layer.
• Refining the plant steroid hormone biosynthesis pathway.
• Short-term immunosuppression and surgical neoangiogenesis with host vessels maintains long-term viability of vascularized bone allografts.
• Students, urinalysis & extracurricular activities: how Vernonia's aftermath is trampling fourth amendment rights.
• The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans.
• The superficial inferior epigastric artery fascia flap in the rabbit.
• Three loci on mouse chromosome 5 and 10 modulate sex determination in XX Ods/+ mice.
• Trastuzumab not for ductal carcinoma in situ?
• Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.