Imaging correlates of axonal swelling in chronic multiple sclerosis brains.

Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Research Abstract Details 

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Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Abstract Text:

Elizabeth Fisher,Ansi Chang,Robert J Fox,Jean A Tkach,Therese Svarovsky,Kunio Nakamura,Richard A Rudick,Bruce D Trapp,

OBJECTIVE: T2-weighted magnetic resonance imaging is a sensitive tool for monitoring progression of multiple sclerosis, but it does not provide information on the severity of the underlying tissue damage. Measurement of T1 hypointensities and magnetization transfer ratio (MTR) can potentially distinguish lesions with more severe tissue damage. The objective of this study was to use image-guided pathology to determine histological differences between lesions that are abnormal only on T2-weighted images versus lesions that are abnormal on T2-weighted, T1-weighted, and MTR images. METHODS: A total of 110 regions were selected from postmortem magnetic resonance images of 10 multiple sclerosis patients. Regions were classified into three magnetic resonance imaging-defined categories: normal-appearing white matter; abnormal on T2-weighted image only (T2-only); and abnormal on T2-weighted, T1-weighted, and MTR images (T2T1MTR). Myelin status, lesion activity, astrocytosis, serum protein distribution, axonal area, and axonal loss were evaluated histopathologically. RESULTS: Comparisons between groups showed that T2T1MTR regions were more likely to be demyelinated (83% compared with 55% of T2-only regions) and more likely to be chronic inactive lesions (68% compared with 0% of demyelinated T2-only regions). There was no difference between T2-only and T2T1MTR regions in axonal area, but there was a significant difference in axonal count, indicating that axons in the T2T1MTR regions were enlarged relative to those in T2-only regions. INTERPRETATION: Axonal swelling and axonal loss were major pathological features that distinguish T2T1MTR regions from T2-only regions.

Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Publishing Authors By Initials

E Fisher,A Chang,RJ Fox,JA Tkach,T Svarovsky,K Nakamura,RA Rudick,BD Trapp,

For similar nervous system: neuroglia: oligodendroglia: myelin sheath research abstracts see: nervous system: neuroglia: oligodendroglia: myelin sheath research

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Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of neurology

VOLUME: 62

Page Numbers: 219-28

Journal Abbreviation: Ann. Neurol.

ISSN: 0364-5134

DAY: 3

MONTH: Sep

YEAR: 2007

Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7707449

Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Keywords Mesh Terms:

KEYWORDS: Myelin Sheath

MESH TERMS: pathology

Chemical & Substance for Abstract: Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Information

Substance Name: Blood Proteins

Registry Number: 0

Grant and Affiliation Information for Imaging correlates of axonal swelling in chronic multiple sclerosis brains.

AFFILIATION: Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH 44195, USA. fishere@ccf.org

Country: United States

AGENCY: United States NINDS

GRANT: P01 NS38667

ACRONYM: NS

MEDLINETA: Ann Neurol

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