Imaging brain activity during natural vision using CASL perfusion fMRI.

Imaging brain activity during natural vision using CASL perfusion fMRI. Research Abstract Details 

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Imaging brain activity during natural vision using CASL perfusion fMRI. Abstract Text:

Hengyi Rao,Jiongjiong Wang,Kathy Tang,Wei Pan,John A Detre,

Functional MRI (fMRI) has begun to be used to explore human brain activity during ecological and natural conditions. Arterial spin labeling (ASL) perfusion fMRI provides an appealing approach for imaging sustained brain activity during natural conditions because of its long-term temporal stability and ability to noninvasively quantify absolute cerebral blood flow (CBF). The present study used ASL perfusion fMRI to measure brain activation patterns associated with natural vision by concurrently recording CBF and blood oxygen level-dependent (BOLD) contrasts while subjects were freely viewing a cartoon movie. Reliable quantitative whole-brain CBF values ( approximately 60 mL/100g/min) as well as regional CBF values (45 approximately 80 mL/100g/min) were measured during movie viewing and resting states. The perfusion contrast revealed CBF increases in multiple visual pathway areas and frontal areas, and CBF decreases in ventromedial frontal cortex and superior temporal cortex during movie viewing compared to resting states. Concurrent BOLD contrast revealed similar but weaker activation and deactivation patterns. Regression analyses of both CBF data and BOLD data showed significant associations between activation in the middle temporal (MT) region and subjects' perception of motion. Region of interest analysis based on a priori literature-defined MT demonstrated significant monotonic stepwise associations between the intensity of motion perception and the CBF and BOLD signal changes. These results demonstrate the feasibility of using ASL perfusion fMRI for imaging both sustained and dynamic effects in neural activation during natural and ecologically valid situations, and support the notion of maintained functional segregation and specialization during natural vision.

Imaging brain activity during natural vision using CASL perfusion fMRI. Publishing Authors By Initials

H Rao,J Wang,K Tang,W Pan,JA Detre,

For similar sensation: vision research abstracts see: sensation: vision research

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Imaging brain activity during natural vision using CASL perfusion fMRI. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Human brain mapping

VOLUME: 28

Page Numbers: 593-601

Journal Abbreviation:

ISSN: 1065-9471

DAY: 3

MONTH: Jul

YEAR: 2007

Imaging brain activity during natural vision using CASL perfusion fMRI. Information

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LANGUAGE: eng

NlmUniqueID: 9419065

Imaging brain activity during natural vision using CASL perfusion fMRI. Keywords Mesh Terms:

KEYWORDS: Vision

MESH TERMS: physiology

Chemical & Substance for Abstract: Imaging brain activity during natural vision using CASL perfusion fMRI. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Imaging brain activity during natural vision using CASL perfusion fMRI.

AFFILIATION: Department of Neurology, Center of Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. hengyi@mail.med.upenn.edu

Country: United States

AGENCY: United States NIDA

GRANT: DA-015149

ACRONYM: DA

MEDLINETA: Hum Brain Mapp

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