Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung.

Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. Research Abstract Details 

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Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. Abstract Text:

Tobias Schroeder,Marcos F Vidal Melo,Guido Musch,R Scott Harris,Jose G Venegas,Tilo Winkler,Tobias Schroeder,Marcos F Vidal Melo,Guido Musch,R Scott Harris,Jose G Venegas,Tilo Winkler,

Pulmonary uptake of (18)F-FDG assessed with PET has been used to quantify the metabolic activity of inflammatory cells in the lung. This assessment involves modeling of tracer kinetics and knowledge of a time-activity curve in pulmonary artery plasma as an input function, usually acquired by manual blood sampling. This paper presents and validates a method to accurately derive an input function from a blood-pool region of interest (ROI) defined in dynamic PET images. METHODS: The method is based on a 2-parameter model describing the activity of blood and that from spillover into the time-activity curve for the ROI. The model parameters are determined using an iterative algorithm, with 2 blood samples used to calibrate the raw PET-derived activity data. We validated both the 2-parameter model and the method to derive a quantitative input function from ROIs defined for the cavities of the right and left heart and for the descending aorta by comparing them against the time-activity curve obtained by manual blood sampling from the pulmonary artery in lungs with acute inflammation. RESULTS: The model accurately described the time-activity curve from sampled blood. The 2-sample calibration method provided an efficient algorithm to derive input functions that were virtually identical to those sampled manually, including the fast kinetics of the early phase. The (18)F-FDG uptake rates in acutely injured lungs obtained using this method correlated well with those obtained exclusively using manual blood sampling (R(2) > 0.993). Within some bounds, the model was found quite insensitive to the timing of calibration blood samples or the exact definition of the blood-pool ROIs. CONCLUSION: Using 2 mixed venous blood samples, the method accurately assesses the entire time course of the pulmonary (18)F-FDG input function and does not require the precise geometry of a specific blood-pool ROI or a population-based input function. This method may substantially facilitate studies involving modeling of pulmonary (18)F-FDG in patients with viral or bacterial infections, pulmonary fibrosis, and chronic obstructive pulmonary disease.

Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. Publishing Authors By Initials

T Schroeder,MF Vidal Melo,G Musch,RS Harris,JG Venegas,T Winkler,T Schroeder,MF Vidal Melo,G Musch,RS Harris,JG Venegas,T Winkler,

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Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of nuclear medicine : official publication

VOLUME: 48

Page Numbers: 1889-96

Journal Abbreviation: J. Nucl. Med.

ISSN: 0161-5505

DAY: 17

MONTH: 10

YEAR: 2007

Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. Information

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LANGUAGE: eng

NlmUniqueID: 217410

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Grant and Affiliation Information for Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung.

AFFILIATION: Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. tschroder@partners.org

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL086827

ACRONYM: HL

MEDLINETA: J Nucl Med

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