Illuminating the role of caspases during Drosophila oogenesis.

Illuminating the role of caspases during Drosophila oogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Illuminating the role of caspases during Drosophila oogenesis. Abstract Text:

S Mazzalupo,L Cooley,

Cell death is a prominent feature of animal germline development. In Drosophila, the death of 15 nurse cells is linked to the development of each oocyte. In addition, females respond to poor environmental conditions by inducing egg chamber death prior to yolk uptake by the oocyte. To study these two forms of cell death, we analyzed caspase activity in the germline by expressing a transgene encoding a caspase cleavage site flanked by cyan fluorescent protein and yellow fluorescent protein. When expressed in ovaries undergoing starvation-induced apoptosis, this construct was an accurate reporter of caspase activity. However, dying nurse cells at the end of normal oogenesis showed no evidence of cytoplasmic caspase activity. Furthermore, although expression of the caspase inhibitors p35 or Drosophila inhibitor of apoptosis protein 1 blocked starvation-induced death, it did not affect normal nurse cell death or overall oogenesis in well-fed females. Our data suggest that caspases play no role in developmentally programmed nurse cell death.

Illuminating the role of caspases during Drosophila oogenesis. Publishing Authors By Initials

S Mazzalupo,L Cooley,

For similar genetic structures: genome: genome components: genes: transgenes research abstracts see: genetic structures: genome: genome components: genes: transgenes research

PUBMED ID PMID:

MEDLINE DATE:

Illuminating the role of caspases during Drosophila oogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell death and differentiation

VOLUME: 13

Page Numbers: 1950-9

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 10

MONTH: 03

YEAR: 2006

Illuminating the role of caspases during Drosophila oogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9437445

Illuminating the role of caspases during Drosophila oogenesis. Keywords Mesh Terms:

KEYWORDS: Transgenes

MESH TERMS: cytology

Chemical & Substance for Abstract: Illuminating the role of caspases during Drosophila oogenesis. Information

Substance Name: Caspases

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Illuminating the role of caspases during Drosophila oogenesis.

AFFILIATION: Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8005, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM043301

ACRONYM: GM

MEDLINETA: Cell Death Differ

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Illuminating the role of caspases during Drosophila oogenesis Related Publications

• Alcoholism-outpatient and follow-up treatment in a general hospital.
• Alcoholism-outpatient and follow-up treatment in a general hospital.
• Asynchronous integrated optical multiply accumulate with sideways summer.
• Clinical challenge. Tongue--multifocal pyogranulomatous glossitis.
• Electric injury model of murine arterial thrombosis.
• Evidence for a deficiency of coenzyme Q10 in human heart disease.
• Exploring strategies for protein trapping in Drosophila.
• Illuminating the role of caspases during Drosophila oogenesis.
• In situ synthesis of peptide microarrays using ink-jet microdispensing.
• Intracortical grafts of embryonic basal forebrain tissue restore low voltage fast activity in rats with basal forebrain lesions.
• Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis.
• Juxtaglomerular cell tumor in an 8-year-old girl.
• Metycaine, saddle block anesthesia in obstetrics.
• Mononuclear muscle cells in Drosophila ovaries revealed by GFP protein traps.
• Montana's Laboratory for the Study of Insect-Borne Diseases.
• Mouse strain differential neointimal response in vein grafts and wire-injured arteries.
• Open heart surgery.
• Open-heart surgery in patients over sixty years of age.
• Practice-based care coordination: a medical home essential.
• Roentgenographic facsimile; a rapid accurate method for reproducing roentgenograms at a distance via wire or radio transmission.
• Severe aberrant glenohumeral motor patterns in a young female rower: A case report.
• Sixty years of oardiovasoular sugery.
• Solitary papule of the lip in recurrent gastroesophageal carcinoma: an unusual presentation of cutaneous metastasis.
• Spontaneous pneumopericardium.
• Systemic disease in traumatic splenic rupture.
• The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis.
• The clinical significance of a high right diaphragm in the diagnosis of amebiasis and amebic hepatitis.
• The immunomodulatory Pseudomonas aeruginosa signalling molecule N-(3-oxododecanoyl)-L-homoserine lactone enters mammalian cells in an unregulated fashion.
• Tuberculous pericarditis; report of a case with a 10-year follow-up.
• Typical albino retinofugal projections despite severe congenital optic nerve malformations in adult albino rats.