Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis.

Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Research Abstract Details 

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Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Abstract Text:

Mauricio J Reginato,Senthil K Muthuswamy,

The lumens present in ductal structures are required for transport of fluids and air. Studies in model organisms and cells in culture suggest that lumens can be generated by multiple mechanisms including apoptosis of centrally located cells, and re-modeling of epithelia. Several studies point to a role for apoptosis during lumen formation in the mammary ducts. However, a role for other mechanisms during lumen formation in the mammary ducts is largely unexplored. Understanding how lumens are formed and maintained free of cells is of clinical importance because filling of the luminal space is associated with cancer and inflammation. Thus, further investigation can lead to new diagnostic and therapeutic opportunities.

Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Publishing Authors By Initials

MJ Reginato,SK Muthuswamy,

For similar neoplasms: precancerous conditions research abstracts see: neoplasms: precancerous conditions research

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Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of mammary gland biology and neoplasia

VOLUME: 11

Page Numbers: 205-11

Journal Abbreviation:

ISSN: 1083-3021

DAY: 3

MONTH: Oct

YEAR: 2006

Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Information

Number of References: 59

LANGUAGE: eng

NlmUniqueID: 9601804

Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Keywords Mesh Terms:

KEYWORDS: Precancerous Conditions

MESH TERMS: pathology

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Grant and Affiliation Information for Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis.

AFFILIATION: Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, 245 N. 15th Street, Philadelphia, PA 19102, USA. mreginat@drexelmed.edu

Country: United States

AGENCY: United States NCI

GRANT: CA098830

ACRONYM: CA

MEDLINETA: J Mammary Gland Biol Neoplasia

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