Ile-phe dipeptide self-assembly: clues to amyloid formation.

Ile-phe dipeptide self-assembly: clues to amyloid formation. Research Abstract Details 

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Ile-phe dipeptide self-assembly: clues to amyloid formation. Abstract Text:

de Groot,Teodor Parella,Francesc X Aviles,Josep Vendrell,Salvador Ventura, de Groot,Teodor Parella,Francesc X Aviles,Josep Vendrell,Salvador Ventura,

Peptidic self-assembled nanostructures are said to have a wide range of applications in nanotechnology, yet the mechanistic details of hierarchical self-assembly are still poorly understood. The Phe-Phe recognition motif of the Alzheimer's Abeta peptide is the smallest peptide able to assemble into higher-order structures. Here, we show that the Ile-Phe dipeptide analog is also able to self-associate in aqueous solution as a transparent, thermoreversible gel formed by a network of fibrillar nanostructures that exhibit strong birefringence upon Congo red binding. Besides, a second dipeptide Val-Phe, differing only in a methyl group from the former, is unable to self-assemble. The detailed analysis of the differential polymeric behavior of these closely related molecules provides insight into the forces triggering the first steps in self-assembly processes such as amyloid formation.

Ile-phe dipeptide self-assembly: clues to amyloid formation. Publishing Authors By Initials

NS de Groot,T Parella,FX Aviles,J Vendrell,S Ventura,NS de Groot,T Parella,FX Aviles,J Vendrell,S Ventura,

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Ile-phe dipeptide self-assembly: clues to amyloid formation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biophysical journal

VOLUME: 92

Page Numbers: 1732-41

Journal Abbreviation: Biophys. J.

ISSN: 0006-3495

DAY: 15

MONTH: 12

YEAR: 2006

Ile-phe dipeptide self-assembly: clues to amyloid formation. Information

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LANGUAGE: eng

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AFFILIATION: Departament de Bioquímica i Biologia Molecular, Servei de Ressonància Magnètica Nuclear, and Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra (Barcelona), Spain.

Country: United States

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MEDLINETA: Biophys J

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