IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells.

IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Abstract Text:

Agatha Vranjkovic,Angela M Crawley,Katrina Gee,Ashok Kumar,Jonathan B Angel,Agatha Vranjkovic,Angela M Crawley,Katrina Gee,Ashok Kumar,Jonathan B Angel,Agatha Vranjkovic,Angela M Crawley,Katrina Gee,Ashok Kumar,Jonathan B Angel,

IL-7 receptor alpha (CD127) signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis. Fewer CD8(+) T cells from HIV-infected patients express CD127 compared with healthy individuals, suggesting that specific host and/or viral factors regulate IL-7 receptor expression. Factors relevant to HIV infection that could potentially decrease CD127 expression on human CD8(+) T cells and the mechanisms by which this occurs were therefore evaluated. IL-7, but not HIV gp120, IL-1-beta, IL-6, IL-10, IL-13, transforming growth factor-beta or tumor necrosis factor-alpha, reduced CD127-surface expression and did so without altering CD127 mRNA expression. Furthermore, IL-7 did not increase the amount of cytoplasmic CD127 in CD8(+) T cells. Interestingly, IL-7 induced the shedding of CD127 from CD8(+) T cells, suggesting a mechanism that may contribute to the increased concentration of CD127 in the plasma of HIV(+) individuals, a novel finding reported here. Naive CD8(+) T cells are more sensitive to IL-7 that mediated the down-regulation of CD127, suggesting that these effects may have particular significance early in T-cell life cycle. Since CD127 down-regulation may be an important contributor to HIV-associated T-cell dysfunction, determining the mechanism thereof may prove to be of considerable significance.

IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Publishing Authors By Initials

A Vranjkovic,AM Crawley,K Gee,A Kumar,JB Angel,A Vranjkovic,AM Crawley,K Gee,A Kumar,JB Angel,A Vranjkovic,AM Crawley,K Gee,A Kumar,JB Angel,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International immunology

VOLUME: 19

Page Numbers: 1329-39

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 22

MONTH: 10

YEAR: 2007

IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8916182

IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells.

AFFILIATION: Ottawa Health Research Institute, Ottawa, Ontario, Canada.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

IL-7 decreases IL-7 receptor {alpha} CD127 expression and induces the shedding of CD127 by human CD8+ T cells Related Publications

• A Macedonian refuge area and stability of type.
• A review of the capacity for nutritional strategies to address environmental challenges in poultry production.
• An analysis of the effect of 1,2-dihydroxybenzene on transmission through the dorsal column sensory pathway.
• Characteristics of hepatitis C virus infection in HIV-infected people.
• Electromyography during voluntary movement: the two-burst pattern.
• Extent of myocardial ischemia during coronary occlusion in single vessel disease. A comparison between patients with exercise-induced angina and patients with recurrent angina at rest.
• Further results for antiplane scattering by a thin strip.
• Histones and histone modifications in protozoan parasites.
• Hydrocodone/Acetaminophen and Tramadol Chlorhydrate Combination Tablets for the Management of Chronic Cancer Pain: A Double-blind Comparative Trial.
• IL-7 decreases IL-7 receptor {alpha} (CD127) expression and induces the shedding of CD127 by human CD8+ T cells.
• Interactions between protease inhibitors and acid-reducing agents: a systematic review.
• Low-cost, broadband static phase plate for generating atmosphericlike turbulence.
• Mobility after amputation for failed knee replacement.
• Omphalocele, bladder exstrophy, imperforate anus, spine defects complex, and bilateral cleft lip and palate in one product of a triplet pregnancy obtained by in vitro fertilization: a case report.
• Open reduction of the severely slipped upper femoral epiphysis.
• Operating-table arm-rest.
• Pachydermo-periostosis (idiopathic osteoarthropathy).
• Problems in determination of skeletal lead burden in archaeological samples: an example from the First African Baptist Church population.
• RAGE signaling sustains inflammation and promotes tumor development.
• Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior.
• Replacement of the femoral head by open operation in severe adolescent slipping of the upper femoral epiphysis.
• The evaluation of a field kit for the determination of serum bicarbonate and chloride.
• Toxoplasma gondii Hsp20 is a stripe-arranged chaperone-like protein associated with the outer leaflet of the inner membrane complex.
• Unloading reflex of a hand muscle.
• What's the best sun protection to use?
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [The question of metaplastic ectopy of the vaginal cervix.]
• [WOUNDS OF THE HEART.]