IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals.

IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals. Research Abstract Details 

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IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals. Abstract Text:

Lien H Ho,Tatsukuni Ohno,Keisuke Oboki,Naoki Kajiwara,Hajime Suto,Motoyasu Iikura,Yoshimichi Okayama,Shizuo Akira,Hirohisa Saito,Stephen J Galli,Susumu Nakae,Lien H Ho,Tatsukuni Ohno,Keisuke Oboki,Naoki Kajiwara,Hajime Suto,Motoyasu Iikura,Yoshimichi Okayama,Shizuo Akira,Hirohisa Saito,Stephen J Galli,Susumu Nakae,Lien H Ho,Tatsukuni Ohno,Keisuke Oboki,Naoki Kajiwara,Hajime Suto,Motoyasu Iikura,Yoshimichi Okayama,Shizuo Akira,Hirohisa Saito,Stephen J Galli,Susumu Nakae,

The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcepsilonRI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function are poorly understood. We found that IL-33, but not IL-1beta or IL-18, induced IL-13 and IL-6 production by mouse bone marrow-derived, cultured mast cells (BMCMCs) independently of IgE. In BMCMCs incubated with the potently cytokinergic SPE-7 IgE without specific antigen, IL-33, IL-1beta, and IL-18 each promoted IL-13 and IL-6 production, but the effects of IL-33 were more potent than those of IL-1beta or IL-18. IL-33 promoted cytokine production via a MyD88-dependent but Toll/IL-1R domain-containing adaptor-inducing IFN-beta-independent pathway. By contrast, IL-33 neither induced nor enhanced mast cell degranulation. At 200 ng/ml, IL-33 prolonged mast cell survival in the absence of IgE and impaired survival in the presence of SPE-7 IgE, whereas at 100 ng/ml, IL-33 had no effect on mast cell survival in the absence of IgE and reduced mast cell survival in the presence of IgE. These observations suggest potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders.

IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals. Publishing Authors By Initials

LH Ho,T Ohno,K Oboki,N Kajiwara,H Suto,M Iikura,Y Okayama,S Akira,H Saito,SJ Galli,S Nakae,LH Ho,T Ohno,K Oboki,N Kajiwara,H Suto,M Iikura,Y Okayama,S Akira,H Saito,SJ Galli,S Nakae,LH Ho,T Ohno,K Oboki,N Kajiwara,H Suto,M Iikura,Y Okayama,S Akira,H Saito,SJ Galli,S Nakae,

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IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of leukocyte biology

VOLUME: 82

Page Numbers: 1481-90

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 19

MONTH: 09

YEAR: 2007

IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals. Information

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LANGUAGE: eng

NlmUniqueID: 8405628

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Grant and Affiliation Information for IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals.

AFFILIATION: L-235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA. sgalli@stanford.edu.

Country: United States

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MEDLINETA: J Leukoc Biol

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