IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection.

IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Research Abstract Details 

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IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Abstract Text:

Qun Wu,Richard J Martin,John G Rino,Rachel Breed,Raul M Torres,Hong Wei Chu,

IL-23 induces IL-17 production in activated CD4+ T cells and participates in host defense against many encapsulated bacteria. However, whether the IL-23/IL-17 axis contributes to a Mycoplasma pneumoniae (Mp)-induced lung inflammation (e.g., neutrophils) has not been addressed. Using an acute respiratory Mp infection murine model, we found significantly up-regulated lung IL-23p19 mRNA in the early phase of infection (4h), and alveolar macrophages were an important cell source of Mp-induced IL-23. We further showed that Mp significantly increased IL-17 protein levels in bronchoalveolar lavage (BAL). Lung gene expression of IL-17, IL-17C and IL-17F was also markedly up-regulated by Mp in vivo. IL-17 and IL-17F were found to be derived mainly from lung CD4+ T cells, and were increased upon IL-23 stimulation in vitro. In vivo blocking of IL-23p19 alone or in combination with IL-23/IL-12p40 resulted in a significant reduction of Mp-induced IL-17 protein and IL-17/IL-17F mRNA expression, which was accompanied by a trend toward reduced lung neutrophil recruitment, BAL neutrophil activity, and Mp clearance. However, IL-23 neutralization had no effect on Mp-induced lung IL-17C mRNA expression. These results demonstrate that IL-17/IL-17F production is IL-23-dependent in an acute Mp infection, and contributes to neutrophil recruitment and activity in the lung defense against the infection.

IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Publishing Authors By Initials

Q Wu,RJ Martin,JG Rino,R Breed,RM Torres,HW Chu,

For similar bacterial infections and mycoses: bacterial infections: gram-negative bacterial infections: mycoplasmatales infections: mycoplasma infections: pneumonia, mycoplasma research abstracts see: bacterial infections and mycoses: bacterial infections: gram-negative bacterial infections: mycoplasmatales infections: mycoplasma infections: pneumonia, mycoplasma research

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IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbes and infection / Institut Pasteur

VOLUME: 9

Page Numbers: 78-86

Journal Abbreviation: Microbes Infect.

ISSN: 1286-4579

DAY: 15

MONTH: 12

YEAR: 2006

IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Information

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LANGUAGE: eng

NlmUniqueID: 100883508

IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Keywords Mesh Terms:

KEYWORDS: Pneumonia, Mycoplasma

MESH TERMS: microbiology

Chemical & Substance for Abstract: IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Information

Substance Name: Interleukin-23 Subunit p19

Registry Number: 0

Grant and Affiliation Information for IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection.

AFFILIATION: Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA.

Country: France

AGENCY: United States NHLBI

GRANT: P01 HL073907-039001

ACRONYM: HL

MEDLINETA: Microbes Infect

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