IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.

IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Research Abstract Details 

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IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Abstract Text:

Andrea M Cooper,

Although inflammation is an essential component of the protective response to fungi, its dysregulation may significantly worsen fungal diseases. We found here that the IL-23/IL-17 developmental pathway acted as a negative regulator of the Th1-mediated immune resistance to fungi and played an inflammatory role previously attributed to uncontrolled Th1 cell responses. Both inflammation and infection were exacerbated by a heightened Th17 response against Candida albicans and Aspergillus fumigatus, two major human fungal pathogens. IL-23 acted as a molecular connection between uncontrolled fungal growth and inflammation, being produced by dendritic cells in response to a high fungal burden and counter-regulating IL-12p70 production. Both IL-23 and IL-17 subverted the inflammatory program of neutrophils, which resulted in severe tissue inflammatory pathology associated with infection. Our data are the first demonstrating that the IL-23/IL-17 pathway promotes inflammation and susceptibility in an infectious disease model. As IL-23-driven inflammation promotes infection and impairs antifungal resistance, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi.

IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Publishing Authors By Initials

AM Cooper,

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IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of immunology

VOLUME: 37

Page Numbers: 2695-706

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 29

MONTH: Oct

YEAR: 2007

IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Information

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LANGUAGE: eng

NlmUniqueID: 1273201

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Grant and Affiliation Information for IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.

AFFILIATION: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.

Country: Germany

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MEDLINETA: Eur J Immunol

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