IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants.

IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. Research Abstract Details 

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IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. Abstract Text:

William J Burlingham,Robert B Love,Ewa Jankowska-Gan,Lynn D Haynes,Qingyong Xu,Joseph L Bobadilla,Keith C Meyer,Mary S Hayney,Ruedi K Braun,Daniel S Greenspan,Bagavathi Gopalakrishnan,Junchao Cai,David D Brand,Shigetoshi Yoshida,Oscar W Cummings,David S Wilkes,William J Burlingham,Robert B Love,Ewa Jankowska-Gan,Lynn D Haynes,Qingyong Xu,Joseph L Bobadilla,Keith C Meyer,Mary S Hayney,Ruedi K Braun,Daniel S Greenspan,Bagavathi Gopalakrishnan,Junchao Cai,David D Brand,Shigetoshi Yoshida,Oscar W Cummings,David S Wilkes,

Bronchiolitis obliterans syndrome (BOS), a process of fibro-obliterative occlusion of the small airways in the transplanted lung, is the most common cause of lung transplant failure. We tested the role of cell-mediated immunity to collagen type V [col(V)] in this process. PBMC responses to col(II) and col(V) were monitored prospectively over a 7-year period. PBMCs from lung transplant recipients, but not from healthy controls or col(IV)-reactive Goodpasture's syndrome patients after renal transplant, were frequently col(V) reactive. Col(V)-specific responses were dependent on both CD4+ T cells and monocytes and required both IL-17 and the monokines TNF-alpha and IL-1beta. Strong col(V)-specific responses were associated with substantially increased incidence and severity of BOS. Incidences of acute rejection, HLA-DR mismatched transplants, and induction of HLA-specific antibodies in the transplant recipient were not as strongly associated with a risk of BOS. These data suggest that while alloimmunity initiates lung transplant rejection, de novo autoimmunity mediated by col(V)-specific Th17 cells and monocyte/macrophage accessory cells ultimately causes progressive airway obliteration.

IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. Publishing Authors By Initials

WJ Burlingham,RB Love,E Jankowska-Gan,LD Haynes,Q Xu,JL Bobadilla,KC Meyer,MS Hayney,RK Braun,DS Greenspan,B Gopalakrishnan,J Cai,DD Brand,S Yoshida,OW Cummings,DS Wilkes,WJ Burlingham,RB Love,E Jankowska-Gan,LD Haynes,Q Xu,JL Bobadilla,KC Meyer,MS Hayney,RK Braun,DS Greenspan,B Gopalakrishnan,J Cai,DD Brand,S Yoshida,OW Cummings,DS Wilkes,

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IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 3498-506

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 2

MONTH: Nov

YEAR: 2007

IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. Information

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LANGUAGE: eng

NlmUniqueID: 7802877

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Grant and Affiliation Information for IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants.

AFFILIATION: Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA. burlingham@surgery.wisc.edu

Country: United States

AGENCY: United States NIAID

GRANT: T32-AI052037

ACRONYM: AI

MEDLINETA: J Clin Invest

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