IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells.

IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. Research Abstract Details 

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IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. Abstract Text:

J Laoukili,E Perret,T Willems,A Minty,E Parthoens,O Houcine,A Coste,M Jorissen,F Marano,D Caput,F Tournier,

In animal models of asthma, interleukin-13 (IL-13) induces goblet cell metaplasia, eosinophil infiltration of the bronchial mucosa, and bronchial hyperreactivity, but the basis of its effects on airway epithelia remain unknown. Lesions of the epithelial barrier, frequently observed in asthma and other chronic lung inflammatory diseases, are repaired through proliferation, migration, and differentiation of epithelial cells. An inflammatory process may then, therefore, influence epithelial regeneration. We have thus investigated the effect of IL-13 on mucociliary differentiation of human nasal epithelial cells in primary culture. We show that IL-13 alters ciliated cell differentiation and increases the proportion of secretory cells. IL-13 downregulates the actin-binding protein ezrin and other cytoskeletal components. IL-13 also impairs lateral cell contacts and interferes with the apical localization of ezrin seen in differentiated ciliated cells. In addition, an IL-4 antagonistic mutant protein (Y124D), which binds to the IL-4 receptor alpha subunit, a common chain of IL-4 and IL-13 receptors, inhibits IL-13's effects. IL-13 also decreases ciliary beat frequency in a time- and dose-dependent manner. These results suggest that, in human allergic asthmatic responses, IL-13 affects both ciliated and secretory cell differentiation, leading to airway damage and obstruction.

IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. Publishing Authors By Initials

J Laoukili,E Perret,T Willems,A Minty,E Parthoens,O Houcine,A Coste,M Jorissen,F Marano,D Caput,F Tournier,

For similar proteins: phosphoproteins research abstracts see: proteins: phosphoproteins research

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IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of clinical investigation

VOLUME: 108

Page Numbers: 1817-24

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 30

MONTH: Dec

YEAR: 2001

IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. Information

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LANGUAGE: eng

NlmUniqueID: 7802877

IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. Keywords Mesh Terms:

KEYWORDS: Phosphoproteins

MESH TERMS: analysis

Chemical & Substance for Abstract: IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. Information

Substance Name: Interleukin-4

Registry Number: 207137-56-2

Grant and Affiliation Information for IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells.

AFFILIATION: Laboratoire de Cytophysiologie et Toxicologie Cellulaire, Université Paris 7, Paris, France.

Country: United States

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MEDLINETA: J Clin Invest

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