I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory.

I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory. Research Abstract Details 

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I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory. Abstract Text:

Maria N Obreztchikova,Kornelis W Patberg,Alexei N Plotnikov,Nazira Ozgen,Irina N Shlapakova,Andrew V Rybin,Eugene A Sosunov,Peter Danilo,Evgeny P Anyukhovsky,Richard B Robinson,Michael R Rosen,

OBJECTIVE: Cardiac memory (CM) is characterized by an altered T-wave morphology, which reflects altered repolarization gradients. We hypothesized that the delayed rectifier currents, I(Kr) and I(Ks), might contribute to these repolarization changes. METHODS: We studied conscious, chronically instrumented dogs paced from the postero-lateral left ventricular (LV) wall at rates 5-10% faster than sinus rate for 3 weeks. ECGs during sinus rhythm were recorded on days 0, 7, 14 and 21 of pacing. Within 3 weeks, CM achieved steady state, hearts were excised, and epicardial and endocardial tissues and myocytes were studied. RESULTS: In unpaced controls, action potential duration to 50% and 90% repolarization (APD) in epicardium was shorter than in endocardium (P < 0.05); in CM epicardial APD increased at CL > or = 500 ms, while endocardial APD was either unchanged or decreased such that the transmural gradient seen in controls diminished (P < 0.05). A transmural I(Kr) gradient occurred in controls (epicardium>endocardium, P < 0.05) and was reversed in CM. No I(Ks) transmural gradient was found in controls, while in CM endocardial I(Ks) was greater than epicardial at greater than +50 mV. Canine ERG (cERG) mRNA and protein in epicardium > endocardium in controls (P < 0.05), and this difference was lost in CM. Expression levels of KCNQ1 and KCNE1 protein were similar in all groups. CONCLUSIONS: A transcriptionally induced change in epicardial I(Kr) contributes to the altered ventricular repolarization that characterizes CM.

I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory. Publishing Authors By Initials

MN Obreztchikova,KW Patberg,AN Plotnikov,N Ozgen,IN Shlapakova,AV Rybin,EA Sosunov,P Danilo,EP Anyukhovsky,RB Robinson,MR Rosen,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular remodeling research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular remodeling research

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I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cardiovascular research

VOLUME: 71

Page Numbers: 88-96

Journal Abbreviation: Cardiovasc. Res.

ISSN: 0008-6363

DAY: 3

MONTH: 03

YEAR: 2006

I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory. Information

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LANGUAGE: eng

NlmUniqueID: 77427

I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory. Keywords Mesh Terms:

KEYWORDS: Ventricular Remodeling

MESH TERMS: genetics

Chemical & Substance for Abstract: I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory. Information

Substance Name: Potassium Channels, Voltage-Gated

Registry Number: 0

Grant and Affiliation Information for I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory.

AFFILIATION: Center for Molecular Therapeutics, Department of Pharmacology and Pediatrics, College of Physicians and Surgeons of Columbia University, 630 West 168 Street, PH 7West-321, New York, NY 10032, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: HL-67101

ACRONYM: HL

MEDLINETA: Cardiovasc Res

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