Ih without Kir in adult rat retinal ganglion cells.

Ih without Kir in adult rat retinal ganglion cells. Research Abstract Details 

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Ih without Kir in adult rat retinal ganglion cells. Abstract Text:

Sherwin C Lee,Andrew T Ishida,

Antisera directed against hyperpolarization-activated mixed-cation ("I(h)") and K(+) ("K(ir)") channels bind to some somata in the ganglion cell layer of rat and rabbit retina. Additionally, the termination of hyperpolarizing current injections can trigger spikes in some cat retinal ganglion cells, suggesting a rebound depolarization arising from activation of I(h). However, patch-clamp studies showed that rat ganglion cells lack inward rectification or present an inwardly rectifying K(+) current. We therefore tested whether hyperpolarization activates I(h) in dissociated, adult rat retinal ganglion cell somata. We report here that, although we found no inward rectification in some cells, and a K(ir)-like current in a few cells, hyperpolarization activated I(h) in roughly 75% of the cells we recorded from in voltage clamp. We show that this current is blocked by Cs(+) or ZD7288 and only slightly reduced by Ba(2+), that the current amplitude and reversal potential are sensitive to extracellular Na(+) and K(+), and that we found no evidence of K(ir) in cells presenting I(h). In current clamp, injecting hyperpolarizing current induced a slowly relaxing membrane hyperpolarization that rebounded to a few action potentials when the hyperpolarizing current was stopped; both the membrane potential relaxation and rebound spikes were blocked by ZD7288. These results provide the first measurement of I(h) in mammalian retinal ganglion cells and indicate that the ion channels of rat retinal ganglion cells may vary in ways not expected from previous voltage and current recordings.

Ih without Kir in adult rat retinal ganglion cells. Publishing Authors By Initials

SC Lee,AT Ishida,

For similar nervous system: neurons: neurons, afferent: photoreceptors: retinal ganglion cells research abstracts see: nervous system: neurons: neurons, afferent: photoreceptors: retinal ganglion cells research

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Ih without Kir in adult rat retinal ganglion cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurophysiology

VOLUME: 97

Page Numbers: 3790-9

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 3

MONTH: May

YEAR: 2007

Ih without Kir in adult rat retinal ganglion cells. Information

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LANGUAGE: eng

NlmUniqueID: 375404

Ih without Kir in adult rat retinal ganglion cells. Keywords Mesh Terms:

KEYWORDS: Retinal Ganglion Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: Ih without Kir in adult rat retinal ganglion cells. Information

Substance Name: cesium chloride

Registry Number: 7647-17-8

Grant and Affiliation Information for Ih without Kir in adult rat retinal ganglion cells.

AFFILIATION: Section of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616-8519, USA.

Country: United States

AGENCY: United States NEI

GRANT: P30 EY-12576

ACRONYM: EY

MEDLINETA: J Neurophysiol

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