Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.

Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Research Abstract Details 

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Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Abstract Text:

Moriyasu Yamauchi,Masayuki Hashimoto,Kenji Ichiyama,Ryoko Yoshida,Toshikatsu Hanada,Tatsushi Muta,Shizuo Komune,Takashi Kobayashi,Akihiko Yoshimura,Moriyasu Yamauchi,Masayuki Hashimoto,Kenji Ichiyama,Ryoko Yoshida,Toshikatsu Hanada,Tatsushi Muta,Shizuo Komune,Takashi Kobayashi,Akihiko Yoshimura,

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of autoantibodies and lupus nephritis. The [New Zealand black (NZB) x New Zealand white (NZW)]F1 (BWF1) mouse has been recognized as an important animal model of human SLE. The T(h)1-prone phenotype of BWF1 mice has been shown to contribute to the development of the lupus. However, the molecular basis for T(h)1 skewing in BWF1 mice has not been clarified. We noticed that IL-6, IL-12 and other proinflammatory cytokines as well as IkappaB-zeta induction were higher in mature bone marrow-derived dendritic cells (BMDCs) from NZB and BWF1 mice than those from NZW mice. The expression of an IFN-inducible gene Ifi202, a candidate gene for lupus, was almost undetectable in NZW BMDCs. Thus, we hypothesized that Ifi202 is involved in elevated IL-12 production from BWF1 BMDCs. Overexpression of Ifi202 enhanced the LPS-induced IkappaB-zeta, IL-12p40 and NF-kappaB promoter activities, while anti-sense (AS) RNA against Ifi202 strongly suppressed them in a monocytic cell line, RAW 264.7. Furthermore, overexpression of Ifi202 enhanced LPS-induced IL-12p40 and IkappaB-zeta mRNA induction while Ifi202 AS RNA suppressed these in RAW 264.7 cells. In addition, forced expression of Ifi202 enhanced IL-12p40 mRNA induction in NZW BMDCs. Thus, Ifi202 is an important NF-kappaB activator in DCs and involved in IL-12 production, which may account for a T(h)1-prone phenotype of BWF1 mice.

Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Publishing Authors By Initials

M Yamauchi,M Hashimoto,K Ichiyama,R Yoshida,T Hanada,T Muta,S Komune,T Kobayashi,A Yoshimura,M Yamauchi,M Hashimoto,K Ichiyama,R Yoshida,T Hanada,T Muta,S Komune,T Kobayashi,A Yoshimura,

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Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International immunology

VOLUME: 19

Page Numbers: 935-42

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 16

MONTH: 08

YEAR: 2007

Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Information

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LANGUAGE: eng

NlmUniqueID: 8916182

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AFFILIATION: Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Country: England

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MEDLINETA: Int Immunol

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