IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4.

IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4. Research Abstract Details 

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IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4. Abstract Text:

Iain MacArthur,Paul B Mann,Eric T Harvill,Andrew Preston,

The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4. Publishing Authors By Initials

I MacArthur,PB Mann,ET Harvill,A Preston,

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IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of endotoxin research

VOLUME: 13

Page Numbers: 243-7

Journal Abbreviation: J. Endotoxin Res.

ISSN: 0968-0519

DAY: 24

MONTH: 10

YEAR: 2007

IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4. Information

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LANGUAGE: eng

NlmUniqueID: 9433350

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Grant and Affiliation Information for IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4.

AFFILIATION: Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.

Country: England

AGENCY: United States NIAID

GRANT: R01-AI053075-02

ACRONYM: AI

MEDLINETA: J Endotoxin Res

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