[Idiopathic male infertility and partial copy deletion of DAZ gene family]

[Idiopathic male infertility and partial copy deletion of DAZ gene family] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Idiopathic male infertility and partial copy deletion of DAZ gene family] Abstract Text:

Yuan Yang,Cuiying Xiao,Sizhong Zhang,Li Lin,Wei Wei,

OBJECTIVE: To analyze the pattern and prevalence of partial copy deletion of deleted-in-azoospermia (DAZ) gene in the azoospermia factor C(AZFc) region of patients with idiopathic azoospermia or severe oligozoospermia. METHODS: sY581 and sY587 in DAZ gene region were analyzed by polymerase chain reaction-restriction length polymorphism(PCR-RFLP) for its deletion in 197 patients with azoospermia, 166 patients with severe oligozoospermia, and 210 fertile men as controls. RESULTS: Deletion of both DAZ1 and DAZ2 was detected in 18 patients with azoospermia and 10 with severe oligozoospermia, and the prevalence was 9.1% and 6.0% respectively. There was significant difference in deletion rate between the cases and controls. CONCLUSION: The frequency of partial copy deletion of DAZ gene in Chinese idiopathic azoospermia or severe oligozoospermia patients is much higher than that of fertile controls, suggesting that the deletion of DAZ1/DAZ2 may be one of the important genetic etiological factors of spermatogenesis damage. The pattern and prevalence of DAZ partial copy deletion are similar to those of Caucasians populations, and detection of DAZ gene partial copy deletion by PCR-RFLP may be adopted as an additional clinical gene diagnostic measure after AZF microdeletion detection.

[Idiopathic male infertility and partial copy deletion of DAZ gene family] Publishing Authors By Initials

Y Yang,C Xiao,S Zhang,L Lin,W Wei,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Idiopathic male infertility and partial copy deletion of DAZ gene family] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 21

Page Numbers: 444-7

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 13

MONTH: Oct

YEAR: 2004

[Idiopathic male infertility and partial copy deletion of DAZ gene family] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 9425197

[Idiopathic male infertility and partial copy deletion of DAZ gene family] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Idiopathic male infertility and partial copy deletion of DAZ gene family] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Idiopathic male infertility and partial copy deletion of DAZ gene family]

AFFILIATION: Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu,Sichuan, 610041 P.R.China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Idiopathic male infertility and partial copy deletion of DAZ gene family Related Publications

• Detection of the level of urinary FPA in chronic nephritis with renal failure and its clinical implication.
• Effects of ultraviolet B exposure on the expression of proliferating cell nuclear antigen in murine skin.
• In situ encapsulation of horseradish peroxidase in electrospun porous silica fibers for potential biosensor applications.
• [A dynamics model describing edema and its physiological analysis]
• [Application prospect of human-artificial intelligence system in future manned space flight]
• [Appropriate sample size and molecular marker loci in the study of genetic diversity of Ocomelania hupensis]
• [Clinical evaluation of Nickel-titanium rotary instruments Hero 642 in root canal preparation]
• [Clinical study of bioglass for repairing alveolar cleft.]
• [Effects of Low-G preconditioning on contractive ability of left ventricle and contents of endothelin and prostacycline in myocardium of rats after repeated +10 Gz stress]
• [Experimental research on the prediction of human body thermal responses in special hot environment]
• [Factors influencing agrobacterium-mediated transformation of maize elite inbred lines]
• [HPLC analysis of microcystin-RR, YR and LR from Dianshan Lake]
• [Idiopathic male infertility and partial copy deletion of DAZ gene family]
• [Immunization with dendritic cells infected with human AFP adenovirus vector effectively elicits immunity against mouse hepatocellular carcinomas]
• [Improvement of grating spectrograph and its application to frequency-doubling in PPLN]
• [One case of encephalopathia caused by lead poisoning.]
• [Reemphasis of pathologic study of coronary heart disease]
• [Regulatory effect of 17beta-estradiol on expression of orphan nuclear receptor ERRalpha in endometrial carcinoma cell lines]
• [Relationship between the expression of murine double minute 2 oncogene and non-Hodgkin lymphoma in childhood]
• [Study on T lymphocyte recognition of tumor antigens on autologous CML cells]
• [Study on luminescence property of nanocrystalline Y2O3:Eu3+ red phosphor]
• [Study on the geographic information system databases regarding the control of schistosomiasis in Zhongxiang, Hubei province, China]
• [Successful unrelated HLA-mis matched cord blood transplantation in pediatric patients with severe aplastic anemia]
• [Survey and treatment of clonorchiasis in Fushan city]
• [The determination of high content tin in powder samples by line width method]
• [The effect of insulin-like growth factor 1 on the fusion of cranial suture]
• [The effects of epidermal growth factor on the wound healing of deep partial thickness burn in rats]
• [The relationship study on the relationship between procrastination behaviors and bad personality disposition]
• [Transgenic soybean obtained with Agrobacterium tumefaciens-mediated transformation of embryonic tip of soybean mature seeds.]
• [Treatment of acute gastrectasia following liver transplantation with the therapeutic methods of integrated traditional Chinese and western medicine: a report of one case]