Identifying prognostic factors for survival in advanced cancer patients: a prospective study.

Identifying prognostic factors for survival in advanced cancer patients: a prospective study. Research Abstract Details 

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Identifying prognostic factors for survival in advanced cancer patients: a prospective study. Abstract Text:

P T Lam,M W Leung,C Y Tse,P T Lam,M W Leung,C Y Tse,P T Lam,M W Leung,C Y Tse,P T Lam,M W Leung,C Y Tse,

OBJECTIVE: To identify potential prognostic factors affecting the survival in patients with advanced cancer in a local palliative care unit. DESIGN: Prospective cohort study. SETTING: Palliative Care Unit of a regional hospital in Hong Kong. PATIENTS: All advanced cancer in-patients and out-patients who were enrolled into the palliative care service of the United Christian Hospital between January and December 2002 were recruited. MAIN OUTCOME MEASURES: Potential prognostic factors including demographic data, tumour characteristics, blood parameters, functional status, co-morbidities, total symptom score, and psychosocial parameters were recorded upon enrollment. RESULTS: A total of 170 patients were eligible for analysis; their mean age was 69 (standard deviation, 12) years, of which 106 (62%) were male. Overall median survival was 77 (interquartile range, 31-160) days. The most frequent primary malignancy was lung (n=58, 34%), followed by liver (n= 24, 14%) and lower gastro-intestinal tract (n=24, 14%). By univariate analysis, 11 factors affected survival, including: age (P=0.040), number of metastatic sites involved (P=0.001), peritoneal metastases (P=0.009), skin metastases (P=0.011), tachycardia (P=0.009), serum albumin concentration (P<0.001), white cell count (P=0.002), Karnofsky Performance Status score (P<0.001), Hamilton Depression Scale score (P=0.004), Edmonton Symptom Assessment System score (P=0.003), and McGill Quality of Life (Hong Kong)-single item score (P=0.002). Multivariable Cox regression analysis revealed that only age (hazard ratio=0.84; 95% confidence interval, 0.73-0.96), number of metastatic sites involved (1.33; 1.13-1.56), serum albumin concentration (0.95; 0.92-0.98), Karnofsky Performance Status score (0.86; 0.78-0.96), and Edmonton Symptom Assessment System score (1.22; 1.05-1.41) were independent prognosticators. CONCLUSION: Age, number of involved metastatic sites, serum albumin, Karnofsky Performance Scale score, and Edmonton Symptom Assessment System score were independent prognosticators. Further studies are needed to provide a prognostic instrument applicable in local clinical settings.

Identifying prognostic factors for survival in advanced cancer patients: a prospective study. Publishing Authors By Initials

PT Lam,MW Leung,CY Tse,PT Lam,MW Leung,CY Tse,PT Lam,MW Leung,CY Tse,PT Lam,MW Leung,CY Tse,

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Identifying prognostic factors for survival in advanced cancer patients: a prospective study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hong Kong medical journal = Xianggang yi xue za zh

VOLUME: 13

Page Numbers: 453-9

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ISSN: 1024-2708

DAY: 6

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong. lampt@ha.org.hk

Country: China

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MEDLINETA: Hong Kong Med J

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