Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs.

Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs. Research Abstract Details 

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Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs. Abstract Text:

Elizabeth A Stemmler,Braulio Peguero,Emily A Bruns,Patsy S Dickinson,Andrew E Christie,

In most invertebrates, multiple species-specific isoforms of tachykinin-related peptide (TRP) are common. In contrast, only a single conserved TRP isoform, APSGFLGMRamide, has been documented in decapod crustaceans, leading to the hypothesis that it is the sole TRP present in this arthropod order. Previous studies of crustacean TRPs have focused on neuronal tissue, but the recent demonstration of TRPs in midgut epithelial cells in Cancer species led us to question whether other TRPs are present in the gut, as is the case in insects. Using direct tissue matrix assisted laser desorption/ionization Fourier transform mass spectrometry, in combination with sustained off-resonance irradiation collision-induced dissociation, we found that at least one additional TRP is present in Cancer irroratus, Cancer borealis, Cancer magister, and Cancer productus. The novel TRP isoform, TPSGFLGMRamide, was present not only in the midgut, but also in the stomatogastric nervous system (STNS). In addition, we identified an unprocessed TRP precursor APSGFLGMRG, which was detected in midgut tissues only. TRP immunohistochemistry, in combination with preadsorption studies, suggests that APSGFLGMRamide and TPSGFLGMRamide are co-localized in the stomatogastric ganglion (STG), which is contained within the STNS. Exogenous application of TPSGFLGMRamide to the STG elicited a pyloric motor pattern that was identical to that elicited by APSGFLGMRamide, whereas APSGFLGMRG did not alter the pyloric motor pattern.

Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs. Publishing Authors By Initials

EA Stemmler,B Peguero,EA Bruns,PS Dickinson,AE Christie,

For similar peptides: intercellular signaling peptides and proteins: kinins: tachykinins research abstracts see: peptides: intercellular signaling peptides and proteins: kinins: tachykinins research

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Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neurochemistry

VOLUME: 101

Page Numbers: 1351-66

Journal Abbreviation: J. Neurochem.

ISSN: 0022-3042

DAY: 16

MONTH: 04

YEAR: 2007

Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985190

Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs. Keywords Mesh Terms:

KEYWORDS: Tachykinins

MESH TERMS: chemistry

Chemical & Substance for Abstract: Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs. Information

Substance Name: Tachykinins

Registry Number: 0

Grant and Affiliation Information for Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs.

AFFILIATION: Department of Chemistry, Bowdoin College, Brunswick, Maine 04011, USA. estemmle@bowdoin.edu

Country: England

AGENCY: United States NCRR

GRANT: P20 RR016463

ACRONYM: RR

MEDLINETA: J Neurochem

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