Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane.

Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Research Abstract Details 

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Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Abstract Text:

Hiroki Kato,Katsuyoshi Mihara,Hiroki Kato,Katsuyoshi Mihara,

The fungal preprotein translocase of the mitochondrial outer membrane (TOM complex) comprises import receptors Tom70, Tom20, and Tom22, import channel Tom40, and small Tom proteins Tom5, Tom6, and Tom7, which regulate TOM complex assembly. These components are conserved in mammals; unlike the other components, however, Tom5 and Tom6 remain unidentified in mammals. We immuno-isolated the TOM complex from HeLa cells expressing hTom22-FLAG and identified the human counterparts of Tom5 and Tom6, together with the other components including Tom7. These small Tom proteins are associated with Tom40 in the TOM complex. Knockdown of Tom7, but not Tom5 and Tom6, strongly compromised stability of the TOM complex. Conversely, knockdown of hTom40 decreased the level of all small Tom proteins. Matrix import of preprotein was affected by double knockdown of any combination of small Tom proteins. These results indicate that human small Tom proteins maintain the structural integrity of the TOM complex.

Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Publishing Authors By Initials

H Kato,K Mihara,H Kato,K Mihara,

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Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 369

Page Numbers: 958-63

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ISSN: 1090-2104

DAY: 10

MONTH: 03

YEAR: 2008

Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Information

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LANGUAGE: eng

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Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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