Identification of the transactivating region of the homeodomain protein, hex.

Identification of the transactivating region of the homeodomain protein, hex. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Identification of the transactivating region of the homeodomain protein, hex. Abstract Text:

Shinya Kasamatsu,Ayuko Sato,Taichi Yamamoto,Vincent W Keng,Hiroshi Yoshida,Yuka Yamazaki,Masafumi Shimoda,Jun-ichi Miyazaki,Tamio Noguchi,

The homeodomain-containing protein Hex acts as an activator as well as a repressor of transcription in animals. While its repression domain has been mapped to the amino-terminal region, the activation domain has never been identified. Here, we show that the homeodomain and the acidic carboxyl-terminal region are necessary for full activation of the sodium-dependent bile acid cotransporter gene promoter in a cell type-independent manner, suggesting that the carboxyl-terminal region comprising residues 197 to 271 functions as the activation domain. In addition, we observed that a Hex mutant without this activation domain acts as a dominant-negative mutant as to the transactivating function of Hex.

Identification of the transactivating region of the homeodomain protein, hex. Publishing Authors By Initials

S Kasamatsu,A Sato,T Yamamoto,VW Keng,H Yoshida,Y Yamazaki,M Shimoda,J Miyazaki,T Noguchi,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

PUBMED ID PMID:

MEDLINE DATE:

Identification of the transactivating region of the homeodomain protein, hex. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 135

Page Numbers: 217-23

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 2004

Identification of the transactivating region of the homeodomain protein, hex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Identification of the transactivating region of the homeodomain protein, hex. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: physiology

Chemical & Substance for Abstract: Identification of the transactivating region of the homeodomain protein, hex. Information

Substance Name: Luciferases

Registry Number: EC 1.13.12.-

Grant and Affiliation Information for Identification of the transactivating region of the homeodomain protein, hex.

AFFILIATION: Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Identification of the transactivating region of the homeodomain protein, hex Related Publications

• Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain.
• Changes in cell culture temperature alter release of inflammatory mediators in murine macrophagic RAW264.7 cells.
• Characterization of folding pathways of the type-1 and type-2 periplasmic binding proteins MglB and ArgT.
• Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer.
• DDX39, Upregulated in Lung Squamous Cell Cancer, Displays RNA Helicase Activities and Promotes Cancer Cell Growth.
• Detection of fast fiber recruitment by multiresolution analysis of surface electromyograms.
• Effect of Oriental Plant Drugs on Platelet Aggregation II1. Effect of Qian-Hu Coumarins on Human Platelet Aggregation.
• Effect of Oriental Plant Drugs on Platelet Aggregation; III1. Effect of Chines Drug "Xiebai" on Human Platelet Aggregation.
• Effects of Er,Cr:YSGG Laser Irradiation on the Root Surface: Morphologic Analysis and Efficiency of Calculus Removal.
• Electrochemical reduction of ferrous alpha-verdoheme in complex with heme oxygenase-1.
• Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity.
• Identification and characterization of the hematopoietic cell-specific enhancer-like element of the mouse hex gene.
• Identification of the transactivating region of the homeodomain protein, hex.
• Increase in respiratory cost at high growth temperature is attributed to high protein turnover cost in Petunia x hybrida petals.
• Is radiofrequency ablation treatment for small breast cancer ready for "prime time"?
• Isolation and characterization of the antigenically distinct proteinpolysaccharide complex from uman aorta.
• New variant of norovirus GII/4 strains prevalent in Yokohama City, October 2006-March 2007.
• Options for immediate breast reconstruction following skin-sparing mastectomy.
• Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.
• Selective expansion of the CD14(+)/CD16(bright) subpopulation of circulating monocytes in patients with hemophagocytic syndrome.
• Serum Hanganutziu and Deicher (HD) antibody and total sialic acid levels in hepatoma patients.
• Sp family members stimulate transcription of the hex gene via interactions with GC boxes.
• Studies on Coumarins of a Chinese Drug "Qian-Hu"; VII1. Structures of New Coumarin-Glycosides of Zi-Huan Quian-Hu and Effect of Coumarin-Glycosides on Human Platelet Aggregation.
• Studies on the catalytic action of poly-alpha-amino acids. 3. Hydrolysis of p-nitrophenyl acetate by the copolymer of tryptophan and glutamic acid.
• Studies on the catalytic activity of poly-alpha-amino acids. II. Hydrolysis of p-nitrophenyl acetate by an interaction between hydroxyl and carboxyl groups of poly (L-tyr-L-glu), copoly (L-tyr, L-glu, L-ala) or copoly (L-tyr, L-glu, L-pro).
• The effect of landiolol on hemodynamics and left ventricular function in patients with coronary artery disease.
• The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN.
• Thermal equilibrium of two conformations in photosensitive nitrile hydratase probed by the FTIR band of nitric oxide bound to the non-heme iron center.
• [Examination strategy for thyroid nodule]
• [Online-conference using JGN.]