Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1.

Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1. Research Abstract Details 

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Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1. Abstract Text:

Junsoo Park,Myung-Shin Lee,Seung-Min Yoo,Kwi Wan Jeong,Daeyoup Lee,Joonho Choe,Taegun Seo,Junsoo Park,Myung-Shin Lee,Seung-Min Yoo,Kwi Wan Jeong,Daeyoup Lee,Joonho Choe,Taegun Seo,

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma. The open reading frame (K9) of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon-mediated signal transduction. The amino-terminal region of vIRF1 displays significant homology to the DNA-binding domain of cellular interferon regulatory factors, supporting the theory that the protein interacts with specific DNA sequences. Here, we identify the consensus sequence of vIRF1-binding sites from a pool of random oligonucleotides. Moreover, our data show that vIRF1 interacts with the K3:viral dihydrofolate reductase:viral interleukin 6 promoter region in the KSHV genome.

Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1. Publishing Authors By Initials

J Park,MS Lee,SM Yoo,KW Jeong,D Lee,J Choe,T Seo,J Park,MS Lee,SM Yoo,KW Jeong,D Lee,J Choe,T Seo,

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Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 12680-4

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 12

MONTH: 09

YEAR: 2007

Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1. Information

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LANGUAGE: eng

NlmUniqueID: 113724

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Grant and Affiliation Information for Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1.

AFFILIATION: Korea Basic Science Institute, Gwangju, Korea. junsoo@kaist.ac.kr

Country: United States

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MEDLINETA: J Virol

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