Identification of potential protein interactors of Lrrk2.

Identification of potential protein interactors of Lrrk2. Research Abstract Details 

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Identification of potential protein interactors of Lrrk2. Abstract Text:

Justus C ,Julie P Taylor,Su San Mok,Owen A Ross,Kelly M Hinkle,Rachel M Bailey,Jacob H Hines,Jennifer Szutu,Benjamin Madden,Leonard Petrucelli,Matthew J Farrer,Justus C ,Julie P Taylor,Su San Mok,Owen A Ross,Kelly M Hinkle,Rachel M Bailey,Jacob H Hines,Jennifer Szutu,Benjamin Madden,Leonard Petrucelli,Matthew J Farrer,

Pathogenic substitutions in the Lrrk2 protein have been shown to be an important cause of both familial and sporadic parkinsonism. The molecular pathway involved in Lrrk2 dopaminergic neuron degeneration remains elusive. Employing a combination of Lrrk2-mediated protein precipitation and tandem mass spectrometry, we identified 14 potential Lrrk2 binding partners. The majority of these interactions may be subgrouped into three functional cellular pathways: (i) chaperone-mediated response, (ii) proteins associated with the cytoskeleton and trafficking and (iii) phosphorylation and kinase activity. Future investigation of these candidates is now warranted and may help resolve the pathomechanism behind Lrrk2 neurodegeneration.

Identification of potential protein interactors of Lrrk2. Publishing Authors By Initials

JC ,JP Taylor,SS Mok,OA Ross,KM Hinkle,RM Bailey,JH Hines,J Szutu,B Madden,L Petrucelli,MJ Farrer,JC ,JP Taylor,SS Mok,OA Ross,KM Hinkle,RM Bailey,JH Hines,J Szutu,B Madden,L Petrucelli,MJ Farrer,

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Identification of potential protein interactors of Lrrk2. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Parkinsonism & related disorders

VOLUME: 13

Page Numbers: 382-5

Journal Abbreviation: Parkinsonism Relat. Disord.

ISSN: 1353-8020

DAY: 2

MONTH: 04

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9513583

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Grant and Affiliation Information for Identification of potential protein interactors of Lrrk2.

AFFILIATION: Department of Neuroscience and Neurology, Mayo Clinic College of Medicine, Birdsall Building, Jacksonville, FL 32224, USA.

Country: England

AGENCY: United States NINDS

GRANT: P50 NS40256

ACRONYM: NS

MEDLINETA: Parkinsonism Relat Disord

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