Identification of origin of unknown derivative chromosomes by array-based comparative genomic hybridization using pre- and postnatal clinical samples.

Identification of origin of unknown derivative chromosomes by array-based comparative genomic hybridization using pre- and postnatal clinical samples. Research Abstract Details 

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Identification of origin of unknown derivative chromosomes by array-based comparative genomic hybridization using pre- and postnatal clinical samples. Abstract Text:

Jin Choe,Jae-Ku Kang,Chang-Jun Bae,Dong-Suk Lee,Doyeong Hwang,Ki-Chul Kim,Woong-Yang Park,Jong-Ho Lee,Jeong-Sun Seo,Jin Choe,Jae-Ku Kang,Chang-Jun Bae,Dong-Suk Lee,Doyeong Hwang,Ki-Chul Kim,Woong-Yang Park,Jong-Ho Lee,Jeong-Sun Seo,

Microarray-based comparative genomic hybridization (array CGH) is a high-resolution and comprehensive method for detecting both genome-wide and chromosome-specific copy-number imbalance. We have developed an array CGH analysis system (consisting of an array CGH chip plus its exclusive analysis software) for constitutional genetic diagnosis and have evaluated the suitability of our system for molecular diagnosis using pre- and postnatal clinical samples. In a blind study, each of the 264 sample karyotypes identified by array CGH analysis was consistent with that identified by traditional karyotype analysis--with one exception, case (47, XXX)--and we were able to identify origins, such as small supernumerary marker chromosomes, which cannot be determined by conventional cytogenetics. We also acquired very accurate, fast and reliable results using a diminutive amount of clinical samples. Taken together, the array CGH platform developed in this study is a rapid, powerful and sensitive technology for pre- and postnatal diagnosis using a very small amount of clinical sample.

Identification of origin of unknown derivative chromosomes by array-based comparative genomic hybridization using pre- and postnatal clinical samples. Publishing Authors By Initials

J Choe,JK Kang,CJ Bae,DS Lee,D Hwang,KC Kim,WY Park,JH Lee,JS Seo,J Choe,JK Kang,CJ Bae,DS Lee,D Hwang,KC Kim,WY Park,JH Lee,JS Seo,

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Identification of origin of unknown derivative chromosomes by array-based comparative genomic hybridization using pre- and postnatal clinical samples. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of human genetics

VOLUME: 52

Page Numbers: 934-42

Journal Abbreviation: J. Hum. Genet.

ISSN: 1434-5161

DAY: 17

MONTH: 10

YEAR: 2007

Identification of origin of unknown derivative chromosomes by array-based comparative genomic hybridization using pre- and postnatal clinical samples. Information

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LANGUAGE: eng

NlmUniqueID: 9808008

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Grant and Affiliation Information for Identification of origin of unknown derivative chromosomes by array-based comparative genomic hybridization using pre- and postnatal clinical samples.

AFFILIATION: Hamchoon Women's Clinic, No. 1621-7, Seocho-1-Dong, Seocho-Ku, Seoul 137-878, Korea.

Country: Japan

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MEDLINETA: J Hum Genet

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