Identification of one vasculature specific phage-displayed peptide in human colon cancer.

Identification of one vasculature specific phage-displayed peptide in human colon cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Identification of one vasculature specific phage-displayed peptide in human colon cancer. Abstract Text:

X Zhao,J Hu,R Huang,L Yang,

Blood vessels of tumors might carry specific markers that are usually related to angiogenesis. Investigating these heterogeneous molecules in different tumor vessels might be beneficial for promoting antiangiogenic therapy. In this study, in vivo screening of phage displayed peptide library was used to identify the peptides binding selectively to endothelial cells of human colon cancer. After four rounds of selection, one phage was obtained with a cyclic 7-mer peptide CPHSKPCLC homing to human colon adenocarcinoma. The results of ELISA and competitive inhibition assay clearly showed that the peptide bound specifically to the colon cancer xenograft in comparision with control organs, such as brain, heart, liver, spleen and kidney. This peptide was also identified to bind more heavily to human umbilical vein endothelial cells (HUVEC) than to gastric cancer cells, esophageal cancer cells, colon cancer cells and liver cancer cells. Immunohistochemical results showed that this phage peptide could bind to the endothelial cells of human colon cancer. The peptide might then be a potential candidate for targeted drug delivery in antivascular therapy and diagnosis of colon cancer.

Identification of one vasculature specific phage-displayed peptide in human colon cancer. Publishing Authors By Initials

X Zhao,J Hu,R Huang,L Yang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Identification of one vasculature specific phage-displayed peptide in human colon cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of experimental & clinical cancer research

VOLUME: 26

Page Numbers: 509-14

Journal Abbreviation: J. Exp. Clin. Cancer Res.

ISSN: 0392-9078

DAY: 27

MONTH: Dec

YEAR: 2007

Identification of one vasculature specific phage-displayed peptide in human colon cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8308647

Identification of one vasculature specific phage-displayed peptide in human colon cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Identification of one vasculature specific phage-displayed peptide in human colon cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Identification of one vasculature specific phage-displayed peptide in human colon cancer.

AFFILIATION: Institute of Digestive Diseases, Subsidary Hospital, the Medical University of Ningxia Province, Yin'chuan, China. xinpanliu16@126.com

Country: Italy

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Exp Clin Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Identification of one vasculature specific phage-displayed peptide in human colon cancer Related Publications

• Application of mucin quantitative competitive reverse transcription polymerase chain reaction in assisting the diagnosis of malignant pleural effusion.
• Aquaporin gene delivery to kidney.
• Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats.
• Late postoperative complication of the foldable lens implantation: opacification of the intraocular lenses.
• Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
• Tissue array technique for p53 expression in human ovarian neoplasms.
• [A case of cerebral schistosomiasis misdiagnosed as brain tumor]
• [Chromosome t (8; 21) and t (15; 17) in a patient with acute myeloid leukemia]
• [Construction of a subtracted cDNA library of differentially expressed genes in human normal liver tissue and primary hepatocellular carcinoma tissue]
• [Control genes of chondrocyte apoptosis in osteoarthritic articular cartilage]
• [Effects of cactus, alove veral, momorcica charantia on reducing the blood glucose of diabetic mice]
• [Force-dependent effects of interleukin-8 gene expression in endothelial cells exposed on fluid shear stress]
• [Human cytomegalovirus inhibits the proliferation of CFU-MK in vitro]
• [Immunorelated pancytopenia]
• [Intro-extro cranial approach treat serious post fronto-orbital fracture deformities]
• [Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study]
• [Patients of severe acute respiratory syndrome with hypoxemia treated by anisodamine]
• [Polylactic acid combined with recombinant human bone morphogenetic protein and basic fibroblast growth factor to repair the mandibular defects in rabbits]
• [Protection on proliferation of intestinal epithelial cells against hypoxia-reoxygenation through recombinant heat shock protein 70 adenovirus transfection]
• [Relationship between the changes of beta2-microglobulin in blood and urine and kidney involvements in children with pneumonia]
• [Research progress on the signal transduction and the molecular regulation of oocyte meiotic maturation]
• [Schistosomiasis investigation at 4 villages of Yangjiayuan during a flood in 1999]
• [Second-line Hycamtin in the treatment of lung cancer]
• [Sequential intensified immunosuppressive therapy combining with hematopoietic growth factors in the treatment of severe aplastic anemia]
• [Seventy degrees lateral decubital intraperiteanal laparoscopic adrenal surgery]
• [Studies on photochemical disinfectant enamelled-ware of toxicity experiments]
• [Study on the transformation from myelodysplastic syndromes into acute leukemias]
• [Surgical management of sacrococcygeal chordomas]
• [The genetic characteristic of HLA-DRB1 locus in the Jiangsu-Zhejiang-Shanghai Han population and a comparison of its frequency distribution with that of other populations]
• [The postburn changes in gastric mucosal blood flow and Na+-K+-ATPase activity and their effects on gastric transmucosal potential difference in severely scalded rats]