Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169.

Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169. Research Abstract Details 

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Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169. Abstract Text:

Yi-Ling Lin,Pei-Ching Chang,Yixiang Wang,Mengtao Li,Yi-Ling Lin,Pei-Ching Chang,Yixiang Wang,Mengtao Li,

Two products of human cytomegalovirus (HCMV) UL111a gene have been previously identified to resemble human IL-10 (hIL-10). These viral IL-10s (vIL-10s) are able to induce signal transduction events and biological activities in a variety of cells. In this study, five novel vIL-10 transcripts were identified from HCMV AD169 infected MRC-5 cells. Some vIL-10 isoforms were post-translationally glycosylated, depending on the existence of a predicted N-linked glycosylation site. Similar to hIL-10, four of the vIL-10 isoforms apparently formed putative dimers. Among the different vIL-10 isoforms, vIL-10A significantly induced the phosphorylation of transcription factor STAT3 in THP-1 cells. All identified vIL-10 isoforms were able to form complexes with hIL-10, and enhanced hIL-10-induced STAT3 phosphorylation in different degrees. Identification of diverse forms of vIL-10 suggests that HCMV has developed a sophisticated mechanism to interfere with hIL-10 signaling pathway.

Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169. Publishing Authors By Initials

YL Lin,PC Chang,Y Wang,M Li,YL Lin,PC Chang,Y Wang,M Li,

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Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virus research

VOLUME: 131

Page Numbers: 213-23

Journal Abbreviation: Virus Res.

ISSN: 0168-1702

DAY: 5

MONTH: 11

YEAR: 2007

Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169.

AFFILIATION: Department of Oral Pathology, University of Kentucky College of Dentistry, 800 Rose Street, Lexington, KY 40536, USA.

Country: Netherlands

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MEDLINETA: Virus Res

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