Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Research Abstract Details 

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Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Abstract Text:

Lawrence N Kwong,Alexandra Shedlovsky,Bryan S Biehl,Linda Clipson,Cheri A Pasch,William F Dove,

The Apc(Min) mouse model of colorectal cancer provides a discrete, quantitative measurement of tumor multiplicity, allowing for robust quantitative trait locus analysis. This advantage has previously been used to uncover polymorphic modifiers of the Min phenotype: Mom1, which is partly explained by Pla2g2a; Mom2, a spontaneous mutant modifier; and Mom3, which was discovered in an outbred cross. Here, we describe the localization of a novel modifier, Mom7, to the pericentromeric region of chromosome 18. Mom7 was mapped in crosses involving four inbred strains: C57BL/6J (B6), BTBR/Pas (BTBR), AKR/J (AKR), and A/J. There are at least two distinct alleles of Mom7: the recessive, enhancing BTBR, AKR, and A/J alleles and the dominant, suppressive B6 allele. Homozygosity for the enhancing alleles increases tumor number by approximately threefold in the small intestine on both inbred and F(1) backgrounds. Congenic line analysis has narrowed the Mom7 region to within 7.4 Mb of the centromere, 28 Mb proximal to Apc. Analysis of SNP data from various genotyping projects suggests that the region could be as small as 4.4 Mb and that there may be five or more alleles of Mom7 segregating among the many strains of inbred mice. This has implications for experiments involving Apc(Min) and comparisons between different or mixed genetic backgrounds.

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Publishing Authors By Initials

LN Kwong,A Shedlovsky,BS Biehl,L Clipson,CA Pasch,WF Dove,

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Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genetics

VOLUME: 176

Page Numbers: 1237-44

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 15

MONTH: 04

YEAR: 2007

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Information

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LANGUAGE: eng

NlmUniqueID: 374636

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.

AFFILIATION: McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA.

Country: United States

AGENCY: United States NCI

GRANT: R37CA63677

ACRONYM: CA

MEDLINETA: Genetics

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