Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling.

Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Research Abstract Details 

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Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Abstract Text:

Satoya Shimizu,Naohiko Seki,Takashi Sugimoto,Shigetoshi Horiguchi,Hideki Tanzawa,Toyoyuki Hanazawa,Yoshitaka Okamoto,Satoya Shimizu,Naohiko Seki,Takashi Sugimoto,Shigetoshi Horiguchi,Hideki Tanzawa,Toyoyuki Hanazawa,Yoshitaka Okamoto,Satoya Shimizu,Naohiko Seki,Takashi Sugimoto,Shigetoshi Horiguchi,Hideki Tanzawa,Toyoyuki Hanazawa,Yoshitaka Okamoto,

DNA amplifications activate oncogenes and are hallmarks of nearly all advanced cancers including head and neck squamous cell carcinoma (HNSCC). Some oncogenes show both DNA copy number gain and mRNA overexpression. Chromosomal comparative genomic hybridization and oligonucleotide microarrays were used to examine 8 HNSCC cell lines and a plot of gene expression levels relative to their position on the chromosome was produced. Three highly up-regulated genes, NT5C3, ANLN and INHBA, were identified on chromosome 7p14. These genes were subjected to quantitative real-time RT-PCR on cDNA and genomic DNA derived from 8 HNSCC cell lines. ANLN and INHBA showed a strong positive correlation between mRNA expression and genomic DNA levels and a similar relationship was shown for the known oncogene, EGFR, at 7p11.2. In clinical samples, ANLN and INHBA showed a significantly higher expression in tumors than in normal tissues. Patients with high expression levels of INHBA had a shorter disease-free survival rate. Therefore, INHBA may be a promising prognostic marker of HNSCC.

Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Publishing Authors By Initials

S Shimizu,N Seki,T Sugimoto,S Horiguchi,H Tanzawa,T Hanazawa,Y Okamoto,S Shimizu,N Seki,T Sugimoto,S Horiguchi,H Tanzawa,T Hanazawa,Y Okamoto,S Shimizu,N Seki,T Sugimoto,S Horiguchi,H Tanzawa,T Hanazawa,Y Okamoto,

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Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncology reports

VOLUME: 18

Page Numbers: 1489-97

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 5

MONTH: Dec

YEAR: 2007

Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling.

AFFILIATION: Department of Otorhinolaryngology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.

Country: Greece

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MEDLINETA: Oncol Rep

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