Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.

Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. Research Abstract Details 

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Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. Abstract Text:

Satoko Ohgaki,Kaoruko Iida,Tomotaka Yokoo,Kazutoshi Watanabe,Rumi Kihara,Hiroaki Suzuki,Hitoshi Shimano,Hideo Toyoshima,Nobuhiro Yamada,

AIM: A number of adipocytokines have been suggested to be involved in the disruption of glucose metabolism, and also in the development of various diabetic complications. We attempted to identify and analyze additional adipocytokines, to better understanding the roles of adipocytes and adipocytokines. METHODS: An oligo-capping signal sequence trap, developed in our laboratory for screening the cDNAs of secretory proteins, was used to sreen cDNAs expressed in mouse white adipose tissue. Profiles of the genes identified in mice and cultured cells were further investigated by northern blotting and luciferase assay. RESULTS: A cDNA fragment of interferon-stimulated gene 12b (ISG12b) was obtained in the search. A northern blot analysis revealed ISG12b to be highly expressed in white adipose tissue. Interferon alpha (IFNalpha) was shown to induce ISG12b expression in the adipose tissue of BL6 mice in vivo, and also in a 3T3-L1 preadipocyte cell line in vitro. The level of ISG12b was higher in mature adipocytes than in preadipocytes. A promoter analysis demonstrated that the 369bp upstream from the transcription initiation site of ISG12b mRNA contain strong promoter activity, and the interferon-stimulated response elements (ISREs) were not present within the 5593bp upstream region. CONCLUSION: ISG12b is an additional candidate for a adipocytokine induced to express in adipose tissue by interferon.

Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. Publishing Authors By Initials

S Ohgaki,K Iida,T Yokoo,K Watanabe,R Kihara,H Suzuki,H Shimano,H Toyoshima,N Yamada,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: germ-free life: specific pathogen-free organisms research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: germ-free life: specific pathogen-free organisms research

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Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of atherosclerosis and thrombosis

VOLUME: 14

Page Numbers: 179-84

Journal Abbreviation: J. Atheroscler. Thromb.

ISSN: 1340-3478

DAY: 14

MONTH: 08

YEAR: 2007

Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9506298

Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. Keywords Mesh Terms:

KEYWORDS: Specific Pathogen-Free Organisms

MESH TERMS: physiology

Chemical & Substance for Abstract: Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. Information

Substance Name: Interferons

Registry Number: 9008-11-1

Grant and Affiliation Information for Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.

AFFILIATION: Department of Internal Medicine (Endocrinology and Metabolism), Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan.

Country: Japan

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MEDLINETA: J Atheroscler Thromb

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