Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.

Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Research Abstract Details 

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Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Abstract Text:

Laura C Cobbold,Keith A Spriggs,Stephen J Haines,Helen C Dobbyn,Christopher Hayes,Cornelia H de Moor,Kathryn S Lilley,Martin Bushell,Anne E Willis,Laura C Cobbold,Keith A Spriggs,Stephen J Haines,Helen C Dobbyn,Christopher Hayes,Cornelia H de Moor,Kathryn S Lilley,Martin Bushell,Anne E Willis,Laura C Cobbold,Keith A Spriggs,Stephen J Haines,Helen C Dobbyn,Christopher Hayes,Cornelia H de Moor,Kathryn S Lilley,Martin Bushell,Anne E Willis,

The proto-oncogenes c-, L-, and N-myc can all be translated by the alternative method of internal ribosome entry whereby the ribosome is recruited to a complex structural element (an internal ribosome entry segment [IRES]). Ribosome recruitment is dependent upon the presence of IRES-trans-acting factors (ITAFs) that act as RNA chaperones and allow the mRNA to attain the correct conformation for the interaction of the 40S subunit. One of the major challenges for researchers in this area is to determine whether there are groups of ITAFs that regulate the IRES-mediated translation of subsets of mRNAs. We have identified four proteins, termed GRSF-1 (G-rich RNA sequence binding factor 1), YB-1 (Y-box binding protein 1), PSF (polypyrimidine tract binding protein-associated splicing factor), and its binding partner, p54nrb, that bind to the myc family of IRESs. We show that these proteins positively regulate the translation of the Myc family of oncoproteins (c-, L-, and N-Myc) in vivo and in vitro. Interestingly, synthesis from the unrelated IRESs, BAG-1 and Apaf-1, was not affected by YB-1, GRSF-1, or PSF levels in vivo, suggesting that these three ITAFs are specific to the myc IRESs. Myc proteins play a role in cell proliferation; therefore, these results have important implications regarding the control of tumorigenesis.

Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Publishing Authors By Initials

LC Cobbold,KA Spriggs,SJ Haines,HC Dobbyn,C Hayes,CH de Moor,KS Lilley,M Bushell,AE Willis,LC Cobbold,KA Spriggs,SJ Haines,HC Dobbyn,C Hayes,CH de Moor,KS Lilley,M Bushell,AE Willis,LC Cobbold,KA Spriggs,SJ Haines,HC Dobbyn,C Hayes,CH de Moor,KS Lilley,M Bushell,AE Willis,

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Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 28

Page Numbers: 40-9

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 1098-5549

DAY: 29

MONTH: 10

YEAR: 2007

Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

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Grant and Affiliation Information for Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.

AFFILIATION: School of Pharmacy, Pharmacy Building, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.

Country: United States

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MEDLINETA: Mol Cell Biol

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