Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).

Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS). Research Abstract Details 

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Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS). Abstract Text:

Ivan R ,Andrea ,Horst-Dieter Ambrosi,Sven Jakupovic,Krishna Saxena,Harald Schwalbe,Markus Kaiser,Herbert Waldmann,Ivan R ,Andrea ,Horst-Dieter Ambrosi,Sven Jakupovic,Krishna Saxena,Harald Schwalbe,Markus Kaiser,Herbert Waldmann,

Protein phosphatases have recently emerged as important targets for research in chemical biology and medicinal chemistry, and new classes of phosphatase inhibitors are in high demand. BIOS (biology-oriented synthesis) employs the criteria of relevance to nature and biological prevalidation for the design and synthesis of compound collections. In an application of the BIOS principle, an efficient solid-phase synthesis of highly substituted indolo[2,3-a]quinolizidines by using a vinylogous Mannich-Michael reaction in combination with phosgene- or acid-mediated ring closure was developed. Screening of this library for phosphatase inhibitors yielded a new inhibitor class for the Mycobacterium tuberculosis phosphatase MptpB.

Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS). Publishing Authors By Initials

IR ,A ,HD Ambrosi,S Jakupovic,K Saxena,H Schwalbe,M Kaiser,H Waldmann,IR ,A ,HD Ambrosi,S Jakupovic,K Saxena,H Schwalbe,M Kaiser,H Waldmann,

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Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chemistry, an Asian journal

VOLUME: 2

Page Numbers: 1109-26

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ISSN: 1861-471X

DAY: 3

MONTH: Sep

YEAR: 2007

Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS). Information

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LANGUAGE: eng

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Grant and Affiliation Information for Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).

AFFILIATION: Max Planck Institute of Molecular Physiology, Department of Chemical Biology, D-44367 Dortmund, Germany.

Country: Germany

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MEDLINETA: Chem Asian J

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