Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes.

Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. Research Abstract Details 

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Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. Abstract Text:

Overproduction of sebum, especially during adolescence, is causally related to acne and inflammation. As a way to reduce sebum and its interference with the process of follicular keratinization in the pilosebaceous unit leading to inflammatory acne lesions, antihistamines were investigated for their effect on sebocytes, the major cell of the sebaceous gland responsible for producing sebum. Reverse transcriptase-PCR analysis and immunofluorescence of an immortalized sebocyte cell line (SZ95) revealed the presence of histamine-1 receptor (H-1 receptor), and thus indicated that histamines and, conversely, antihistamines could potentially modulate sebocyte function directly. When sebocytes were incubated with an H-1 receptor antagonist, diphenhydramine (DPH), at non-cytotoxic doses, a significant decrease in squalene levels, a biomarker for sebum, was observed. As determined by high-performance liquid chromatography, untreated sebocytes contained 6.27 (+/-0.73) nmol squalene per 10(6) cells, whereas for DPH-treated cells, the levels were 2.37 (+/-0.24) and 2.03 (+/-0.97) nmol squalene per 10(6) cells at 50 and 100 muM, respectively. These data were further substantiated by the identification of histamine receptors in human sebaceous glands. In conclusion, our data show the presence of histamine receptors on sebocytes, demonstrate how an antagonist to these receptors modulated cellular function, and may indicate a new paradigm for acne therapy involving an H-1 receptor-mediated pathway.Journal of Investigative Dermatology (2008) 128, 1280-1285; doi:10.1038/sj.jid.5701160; published on line 15 November 2007.

Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. Publishing Authors By Initials

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Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of investigative dermatology

VOLUME: 128

Page Numbers: 1280-5

Journal Abbreviation: J. Invest. Dermatol.

ISSN: 1523-1747

DAY: 15

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes.

AFFILIATION: [1] 1Estee Lauder Research Laboratories, Melville, New York, USA [2] 2Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, New York, USA.

Country: United States

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MEDLINETA: J Invest Dermatol

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