Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis.

Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis. Research Abstract Details 

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Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis. Abstract Text:

Arun Kumar,Syril Kumar Dorairaj,Venkatesh C Prabhakaran,D Ravi Prakash,Sanjukta Chakraborty,Arun Kumar,Syril Kumar Dorairaj,Venkatesh C Prabhakaran,D Ravi Prakash,Sanjukta Chakraborty,Arun Kumar,Syril Kumar Dorairaj,Venkatesh C Prabhakaran,D Ravi Prakash,Sanjukta Chakraborty,

Meibomian cell carcinoma (MCC) is a malignant tumor of the meibomian glands located in the eyelids. No information exists on the cytogenetic and genetic aspects of MCC. There is no report on the gene expression profile of MCC. Thus there is a need, for both scientific and clinical reasons, to identify genes and pathways that are involved in the development and progression of MCC. We analyzed the gene expression profile of MCC by the microarray technique. Forty-four genes were upregulated and 149 genes were downregulated in MCC. Differential expression data were confirmed for 5 genes by semiquantitative RT-PCR in MCC tumors: GTF2H4, RBM12, UBE2D3, DDX17, and LZTS1. We found dysregulation of two major pathways in MCC: MAPK and JAK/STAT. Clusters of genes on chromosomes 1, 12, and 19 were dysregulated in MCC. The data presented here will facilitate the identification of specific markers and therapeutic targets for the treatment of MCC patients.

Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis. Publishing Authors By Initials

A Kumar,S Kumar Dorairaj,VC Prabhakaran,DR Prakash,S Chakraborty,A Kumar,S Kumar Dorairaj,VC Prabhakaran,DR Prakash,S Chakraborty,A Kumar,S Kumar Dorairaj,VC Prabhakaran,DR Prakash,S Chakraborty,

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Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genomics

VOLUME: 90

Page Numbers: 559-66

Journal Abbreviation: Genomics

ISSN: 0888-7543

DAY: 21

MONTH: 09

YEAR: 2007

Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis. Information

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LANGUAGE: eng

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AFFILIATION: Department of Molecular Reproduction, Development, and Genetics, Indian Institute of Science, Bangalore 560012, India.

Country: United States

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MEDLINETA: Genomics

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