Identification of E2F1 as a positive transcriptional regulator for delta-catenin.

Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Research Abstract Details 

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Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Abstract Text:

Kwonseop Kim,Minsoo Oh,Hyunkyoung Ki,Tao Wang,Sonja Bareiss,M Elizabeth Fini,Dawei Li,Qun Lu,

delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have screened several nuclear signaling modulators to test whether they can affect delta-catenin transcription. Among beta-catenin/LEF-1, Notch1, and E2F1, E2F1 dramatically increased delta-catenin-luciferase activities while beta-catenin/LEF-1 induced only a marginal increase. Rb suppressed the upregulation of delta-catenin-luciferase activities induced by E2F1 but did not interact with delta-catenin. RT-PCR and Western blot analyses in 4 different prostate cancer cell lines revealed that regulation of delta-catenin expression is controlled mainly at the transcriptional level. Interestingly, the effects of E2F1 on delta-catenin expression were observed only in human cancer cells expressing abundant endogenous delta-catenin. These studies identify E2F1 as a positive transcriptional regulator for delta-catenin, but further suggest the presence of strong negative regulator(s) for delta-catenin in prostate cancer cells with minimal endogenous delta-catenin expression.

Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Publishing Authors By Initials

K Kim,M Oh,H Ki,T Wang,S Bareiss,ME Fini,D Li,Q Lu,

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Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochemical and biophysical research communication

VOLUME: 369

Page Numbers: 414-20

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 25

MONTH: 02

YEAR: 2008

Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Identification of E2F1 as a positive transcriptional regulator for delta-catenin.

AFFILIATION: Department of Anatomy and Cell Biology, The Brody School of Medicine, East Carolina University, 600 Moye Street, Greenville, NC 27834, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA111891

ACRONYM: CA

MEDLINETA: Biochem Biophys Res Commun

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