Identification of Differentially Expressed Genes in Microsatellite Stable HNPCC and Sporadic Colon Cancer.

Identification of Differentially Expressed Genes in Microsatellite Stable HNPCC and Sporadic Colon Cancer. Research Abstract Details 

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Identification of Differentially Expressed Genes in Microsatellite Stable HNPCC and Sporadic Colon Cancer. Abstract Text:

Won-Suk Lee,Gilju Seo,Hee Jung Shin,Seong Hyeon Yun,Haeran Yun,Naeyun Choi,Jinseon Lee,Daesoon Son,Jisook Cho,Jhingook Kim,Yong Beom Cho,Ho-Kyung Chun,Woo Yong Lee,Won-Suk Lee,Gilju Seo,Hee Jung Shin,Seong Hyeon Yun,Haeran Yun,Naeyun Choi,Jinseon Lee,Daesoon Son,Jisook Cho,Jhingook Kim,Yong Beom Cho,Ho-Kyung Chun,Woo Yong Lee,Won-Suk Lee,Gilju Seo,Hee Jung Shin,Seong Hyeon Yun,Haeran Yun,Naeyun Choi,Jinseon Lee,Daesoon Son,Jisook Cho,Jhingook Kim,Yong Beom Cho,Ho-Kyung Chun,Woo Yong Lee,

BACKGROUND: Some sporadic colon cancers and hereditary nonpolyposis colorectal cancer (HNPCC) have been known by a constitutional defect in mismatch gene repair (MMR) and dysfunction in of this MMR system, which lead to an aberrant phenotype that can cause microsatellite instability. However, the clinicopathologic features of still existing microsatellite stable (MSS) colon cancer remain to be investigated. METHOD: We compared the gene expression patterns of nine tumor tissues of HNPCC and nine tumor tissues of sporadic colon cancer with their adjacent pathologically normal, MSS tissues by modified differential display-polymerase chain reaction, selected four potential marker genes, and confirmed their reproducibility by reverse transcriptase-polymerase chain reaction. RESULTS: Reg I, MLCK, and MYH11 in tumors of MSS HNPCC showed significant differences in gene expression pattern compared with the adjacent pathologically normal tissues (P = 0.028, P = 0.002, and P = 0.001, respectively). Similar differences in expression patterns for the same set of genes were seen between the sporadic colon cancer group and their adjacent pathologically normal tissues (P = 0.012, P = 0.003, and P = 0.002, respectively). CONCLUSION: We suggest that the three cancer-associated differentially expressed genes in MSS sporadic colon cancer or MSS HNPCC might be potential tumor markers.

Identification of Differentially Expressed Genes in Microsatellite Stable HNPCC and Sporadic Colon Cancer. Publishing Authors By Initials

WS Lee,G Seo,HJ Shin,SH Yun,H Yun,N Choi,J Lee,D Son,J Cho,J Kim,YB Cho,HK Chun,WY Lee,WS Lee,G Seo,HJ Shin,SH Yun,H Yun,N Choi,J Lee,D Son,J Cho,J Kim,YB Cho,HK Chun,WY Lee,WS Lee,G Seo,HJ Shin,SH Yun,H Yun,N Choi,J Lee,D Son,J Cho,J Kim,YB Cho,HK Chun,WY Lee,

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Identification of Differentially Expressed Genes in Microsatellite Stable HNPCC and Sporadic Colon Cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of surgical research

VOLUME: 144

Page Numbers: 29-35

Journal Abbreviation: J. Surg. Res.

ISSN: 0022-4804

DAY: 22

MONTH: 10

YEAR: 2007

Identification of Differentially Expressed Genes in Microsatellite Stable HNPCC and Sporadic Colon Cancer. Information

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LANGUAGE: eng

NlmUniqueID: 376340

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Grant and Affiliation Information for Identification of Differentially Expressed Genes in Microsatellite Stable HNPCC and Sporadic Colon Cancer.

AFFILIATION: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Country: United States

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MEDLINETA: J Surg Res

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