Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas.

Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Research Abstract Details 

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Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Abstract Text:

Ivan Martinez,Jun Wang,Kenosha F Hobson,Robert L Ferris,Saleem A Khan,

Human papillomaviruses (HPVs) have been implicated in the pathogenesis of a subset of squamous cell carcinoma of the head and neck (SCCHN). The goal of this study was to compare the cellular gene expression profiles of HPV-positive and HPV-negative oropharyngeal carcinomas with those of the normal oral epithelium. Using Affymetrix Human U133A GeneChip, our results showed that 397 genes were differentially expressed in HPV-positive SCCHN compared to the normal oral epithelium. The upregulated genes included those involved in cell cycle regulation (CDKN2A), cell differentiation (SFRP4) and DNA repair (RAD51AP1), while the downregulated genes included those involved in proteolysis (PRSS3). We also found 162 differentially expressed genes in HPV-negative SCCHN compared to the normal oral mucosa. The upregulated genes included those involved in cell proliferation (AKR1C3) and transcription regulation (SNAPC1), while downregulated genes included those involved in apoptosis (CLU) and RNA processing (RBM3). Our studies also identified a subgroup of 59 differentially expressed genes in HPV-positive SCCHN as compared to both HPV-negative SCCHN and normal oral tissues. Such upregulated genes included those involved in nuclear structure and meiosis (SYCP2), DNA repair (RFC5), and transcription regulation (ZNF238). Genes involved in proteolysis (KLK8) and signal transduction (CRABP2) were found to be downregulated in HPV-positive SCCHN. The results of GeneChip experiments were validated by quantitative real-time RT-PCR analysis of a few representative genes. Our results reveal specific gene expression patterns in HPV-positive and HPV-negative oropharyngeal squamous carcinomas that may serve as potential biomarkers for the development of SCCHN.

Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Publishing Authors By Initials

I Martinez,J Wang,KF Hobson,RL Ferris,SA Khan,

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of cancer (Oxford, England : 1990

VOLUME: 43

Page Numbers: 415-32

Journal Abbreviation: Eur. J. Cancer

ISSN: 0959-8049

DAY: 31

MONTH: 10

YEAR: 2006

Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Information

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LANGUAGE: eng

NlmUniqueID: 9005373

Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: virology

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Grant and Affiliation Information for Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas.

AFFILIATION: Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Room East 1240, 200 Lothrop Street, Pittsburgh, PA 15208, USA.

Country: England

AGENCY: United States NIDCR

GRANT: R01 DE016406-02

ACRONYM: DE

MEDLINETA: Eur J Cancer

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