Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis.

Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Research Abstract Details 

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Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Abstract Text:

Jian-Feng Lin,Jun Xu,Hong-Yu Tian,Xia Gao,Qing-Xi Chen,Qi Gu,Gen-Jun Xu,Jian-da Song,Fu-Kun Zhao,

Although serum prostate specific antigen (PSA) is a well-established diagnostic tool for prostate cancer (PCa) detection, the definitive diagnosis of PCa is based on the information contained in prostate needle biopsy (PNBX) specimens. To define the proteomic features of PNBX specimens to identify candidate biomarkers for PCa, PNBX specimens from patients with PCa or benign prostatic hyperplasia (BPH) were subjected to comparative proteomic analysis. 2-DE revealed that 52 protein spots exhibited statistically significantly changes among PCa and BPH groups. Interesting spots were identified by MALDI-TOF-MS/MS. The 2 most notable groups of proteins identified included latent androgen receptor coregulators [FLNA(7-15) and FKBP4] and enzymes involved in mitochondrial fatty acid beta-oxidation (DCI and ECHS1). An imbalance in the expression of peroxiredoxin subtypes was noted in PCa specimens. Furthermore, different post-translationally modified isoforms of HSP27 and HSP70.1 were identified. Importantly, changes in FLNA(7-15), FKBP4, and PRDX4 expression were confirmed by immunoblot analyses. Our results suggest that a proteomics-based approach is useful for developing a more complete picture of the protein profile of PNBX specimen. The proteins identified by this approach may be useful molecular targets for PCa diagnostics and therapeutics.

Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Publishing Authors By Initials

JF Lin,J Xu,HY Tian,X Gao,QX Chen,Q Gu,GJ Xu,JD Song,FK Zhao,

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Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of cancer. Journal internati

VOLUME: 121

Page Numbers: 2596-605

Journal Abbreviation: Int. J. Cancer

ISSN: 1097-0215

DAY: 15

MONTH: Dec

YEAR: 2007

Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Information

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LANGUAGE: eng

NlmUniqueID: 42124

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AFFILIATION: Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China.

Country: United States

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MEDLINETA: Int J Cancer

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